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首页> 外文期刊>The journal of sexual medicine >Estradiol ameliorates diabetes-induced changes in vaginal structure of db/db mouse model.
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Estradiol ameliorates diabetes-induced changes in vaginal structure of db/db mouse model.

机译：雌二醇改善了糖尿病引起的db / db小鼠模型阴道结构的变化。

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INTRODUCTION: Women with diabetes experience diminished genital arousal, reduced vaginal lubrication, vaginal atrophy, dyspareunia, and increased infections. Limited studies are available investigating the effects of diabetic complications on the vagina. AIMS: The goals of this study were to investigate type 2 diabetes-induced changes in vaginal structure, and to determine if estradiol treatment ameliorates these changes. METHODS: Eight-week-old female diabetic (db/db) mice (strain BKS*Cg-m+/+Lepr(db)/J) and age-matched control normoglycemic female littermates were used to investigate the effects of type 2 diabetes on vaginal tissue structural integrity. Diabetic animals were divided into two subgroups: diabetic treated with vehicle only and diabetic treated with pellets containing estradiol. At 16 weeks, the animals were sacrificed, and the vaginal tissues were excised and analyzed by histological and immunohistochemical methods to assess diabetes-induced changes in vaginal tissue and the extent by which these parameters are restored by estradiol treatment. MAIN OUTCOME MEASURES: The effects of type 2 diabetes and estradiol supplementation were investigated on vaginal histoarchitecture. RESULTS: Diabetic animals exhibited high blood glucose levels (>600 mg/dL), increased body weight (43.0 +/- 6.0 g vs. 24.4 +/- 2.0 g), and reduced plasma estradiol levels (65.5 +/- 6.6 pg/mL vs. 80.77 +/- 13.2 pg/mL) when compared to control animals. Diabetes resulted in significant thinning of the epithelium (P
机译：简介：患有糖尿病的女性的生殖器唤醒减少，阴道润滑减少，阴道萎缩，性交困难和感染增加。有限的研究可用于研究糖尿病并发症对阴道的影响。目的：这项研究的目的是调查2型糖尿病引起的阴道结构变化，并确定雌二醇治疗是否可以改善这些变化。方法：使用八周龄雌性糖尿病（db / db）小鼠（品系BKS * Cg-m + / + Lepr（db）/ J）和年龄匹配的正常血糖雌性同窝仔鼠研究2型糖尿病对糖尿病的影响阴道组织结构完整性。糖尿病动物分为两个亚组：仅用赋形剂治疗的糖尿病和用含雌二醇的小球治疗的糖尿病。在第16周，处死动物，切除阴道组织，并通过组织学和免疫组织化学方法进行分析，以评估糖尿病引起的阴道组织变化以及通过雌二醇治疗恢复这些参数的程度。主要观察指标：研究2型糖尿病和补充雌二醇对阴道组织结构的影响。结果：糖尿病动物表现出高血糖水平（> 600 mg / dL），体重增加（43.0 +/- 6.0 g vs. 24.4 +/- 2.0 g）和血浆雌二醇水平降低（65.5 +/- 6.6 pg /与对照动物相比时，mL vs. 80.77 +/- 13.2 pg / mL）。糖尿病导致上皮明显变薄（P <或= 0.05），肌层面积明显减少（P

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