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首页> 外文期刊>The journal of sexual medicine >Changes in the penile arteries of the rat after fractionated irradiation of the prostate: a pilot study.
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Changes in the penile arteries of the rat after fractionated irradiation of the prostate: a pilot study.

机译：前列腺分次照射后大鼠阴茎动脉的变化：一项初步研究。

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INTRODUCTION: External beam radiotherapy for prostate cancer leads to erectile dysfunction in 36%-43% of patients. The underlying mechanism is largely unknown, although some clinical studies suggest that the arterial supply to the corpora cavernosa is responsible. Two animal experimental studies reported on the effects of a single fraction of prostate irradiation on the penile structures. However, irradiation in multiple fractions is more representative of the actual clinical treatment. AIM: The present prospective, controlled study was initiated to investigate the effect of fractionated prostate irradiation on the arteries of the corpora cavernosa. MAIN OUTCOME MEASURES: Histological evaluation of the penile tissue in comparison with control rats at 2, 4, and 9 weeks after irradiation. METHODS: The prostate of twelve rats was treated with external beam radiation in 5 daily fractions of 7.4 gray. Three control rats were treated with sham irradiation. Prostatic and penile tissue was evaluated for general histology (hematoxylin-eosin). The penile tissue was further evaluated after combined staining for collagen (resorcin fuchsin) and alpha-smooth muscle actin (SMA) (Biogenex). RESULTS: The prostate showed adequate irradiation with fibrosis occurring at 9 weeks after irradiation. The corpora cavernosa showed arteries that had developed loss of smooth muscle cells expressing SMA, thickening of the intima, and occlusions. All the control rats maintained normal anatomy. CONCLUSION: This is the first animal experimental study that demonstrates changes in the arteries of the corpora cavernosa after fractionated irradiation to the prostatic area. The preliminary data suggests that erectile dysfunction after radiotherapy might be caused by radiation damage to the arterial supply of the corpora cavernosa.
机译：引言：用于前列腺癌的外部束放射疗法导致36％-43％的患者出现勃起功能障碍。尽管一些临床研究表明海绵体的动脉供应是负责任的，但其潜在的机制在很大程度上尚不清楚。两项动物实验研究报告了单次前列腺照射对阴茎结构的影响。但是，多次照射更能代表实际的临床治疗。目的：开始本项前瞻性，对照研究，以研究分级前列腺照射对海绵体动脉的影响。主要观察指标：照射后第2、4和9周，与对照组相比，对阴茎组织进行组织学评价。方法：12只大鼠的前列腺接受外照射，每日5次，每次7.4 gray。三只对照大鼠接受假放射治疗。评估前列腺和阴茎组织的一般组织学（苏木精-曙红）。在对胶原蛋白（间苯二酚品红）和α-平滑肌肌动蛋白（SMA）（Biogenex）进行联合染色后，进一步评估阴茎组织。结果：前列腺显示出充足的放射线，在放射后9周发生纤维化。海绵体的动脉显示出表达SMA的平滑肌细胞丢失，内膜增厚和闭塞。所有对照大鼠保持正常的解剖结构。结论：这是第一项动物实验研究，该实验证明了在局部照射前列腺区后海绵体动脉的变化。初步数据表明，放疗后的勃起功能障碍可能是由于辐射破坏了海绵体的动脉供应所致。

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