• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journal of sexual medicine >A randomized trial of oral DHEA treatment for sexual function, well-being, and menopausal symptoms in postmenopausal women with low libido.
【24h】

A randomized trial of oral DHEA treatment for sexual function, well-being, and menopausal symptoms in postmenopausal women with low libido.

机译：口服脱氢表雄酮（DHEA）治疗性欲低的绝经后妇女的性功能，幸福感和绝经期症状的随机试验。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

INTRODUCTION: Dehydroepiandrosterone (DHEA) and its sulfate DHEAS, which are the most abundant steroids in women, decline with age. We have shown association between low sexual function and low circulating DHEAS levels in women. AIM: The aim of this study was to evaluate whether restoration of circulating DHEA levels in postmenopausal women to the levels seen in young individuals improves sexual function. METHODS: Ninety-three postmenopausal women not using concurrent estrogen therapy were enrolled in a 52-week randomized, double-blind, placebo controlled trial and received either DHEA 50 mg or placebo (PL) daily. MAIN OUTCOME MEASURES: Efficacy was assessed through 26 weeks. The main outcome measures were the change in total satisfying sexual events (SSE) and the change in the Sabbatsberg Sexual Self-Rating Scale (SSS) total score. Secondary measures were the Psychological General Well-Being Questionnaire (PGWB), and the Menopause-Specific Quality of Life Questionnaire (MENQOL). Hormonal levels, adverse events (AEs), serious adverse events (SAEs) and clinical labs were evaluated over 52 weeks. RESULTS: Eighty-five participants (91%) were included in the 26-week efficacy analysis. There were no significant differences between the DHEA and PL groups in the change in total SSE per month or the SSS, PGWB, and MENQOL change scores. Overall AE reports and number of withdrawals as a result of AEs were similar in both groups; however more women in the DHEA group experienced androgenic effects of acne and increased hair growth. CONCLUSIONS: In this study treatment of postmenopausal women with low sexual desire with 50 mg/day DHEA resulted in no significant improvements in sexual function over PL therapy over 26 weeks.
机译：简介：脱氢表雄酮（DHEA）及其硫酸盐DHEAS是女性中最丰富的类固醇，随着年龄的增长而下降。我们已经显示出女性低性功能与低循环DHEAS水平之间的关联。目的：本研究的目的是评估绝经后妇女体内循环脱氢表雄酮（DHEA）水平恢复到青年人所见水平是否能改善性功能。方法：一项不使用同步雌激素治疗的93名绝经后妇女参加了一项为期52周的随机，双盲，安慰剂对照试验，每天接受DHEA 50 mg或安慰剂（PL）治疗。主要观察指标：评估疗效至26周。主要的结局指标是总的令人满意的性事件（SSE）的变化和Sabbatsberg性自评量表（SSS）的总分的变化。次要措施是心理一般健康状况调查表（PGWB）和更年期特定生活质量调查表（MENQOL）。在52周内评估了激素水平，不良事件（AE），严重不良事件（SAE）和临床实验室。结果：在26周的疗效分析中纳入了八十五名参与者（91％）。 DHEA和PL组之间每月总SSE的变化或SSS，PGWB和MENQOL的变化得分没有显着差异。两组的总体不良事件报告和因不良事件而退出的人数相似。但是，脱氢表雄酮（DHEA）组中的更多女性经历了痤疮的雄激素作用并增加了头发的生长。结论：在这项研究中，在26周内，每天50 mg脱氢表雄酮（DHEA）治疗性欲低的绝经后妇女的性功能没有明显改善。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号