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首页> 外文期刊>The journal of sexual medicine >Is hyperlipidemia or its treatment associated with erectile dysfunction?: Results from the Boston Area Community Health (BACH) Survey.
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Is hyperlipidemia or its treatment associated with erectile dysfunction?: Results from the Boston Area Community Health (BACH) Survey.

机译：高脂血症或其治疗与勃起功能障碍有关吗？：波士顿地区社区健康（BACH）调查的结果。

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INTRODUCTION: Studies and reports suggest that both hyperlipidemia and its pharmacologic treatment may lead to an increased risk of erectile dysfunction (ED). AIMS: Our objectives were to examine the association between (i) treated hyperlipidemia and ED; and (ii) untreated hyperlipidemia and ED. METHODS: Data from 1,899 men aged 30-79 were used from the Boston Area Community Health Survey of community-dwelling residents of Boston, MA, collected during 2002-2005 using an in-person interview, self-administered questionnaires, and a venous blood draw. MAIN OUTCOME MEASURES: ED was measured using the short form International Index of Erectile Function. A case of treated hyperlipidemia was defined by use of anti-lipemics in the past month, while untreated hyperlipidemia was serum total cholesterol > or =240 milligrams per deciliter with no anti-lipemic use. We estimated associations using odds ratios (ORs) and 95% confidence intervals (CIs) from multivariate logistic regression. RESULTS: Men with treated hyperlipidemia were older, had more comorbidities, and used more medications compared with men with untreated hyperlipidemia or no hyperlipidemia. In multivariate models stratified by age and the presence of diabetes and/or cardiovascular disease (CVD), we saw no association between hyperlipidemia drug treatment and ED, except among younger men (<55) who had diabetes and/or CVD, where a strong association with an imprecise CI was observed (OR = 10.39, 95% CI: 3.25, 33.20). There was no significant positive association between untreated hyperlipidemia and ED in any multivariate model. CONCLUSION: Lipid-lowering medications may be associated with ED among some men. The well-established benefits of lipid-lowering therapy should always be weighed against potential adverse effects.
机译：简介：研究和报告表明，高脂血症及其药物治疗均可能导致勃起功能障碍（ED）的风险增加。目的：我们的目标是检查（i）高脂血症和ED之间的关系; （ii）未经治疗的高脂血症和ED。方法：从马萨诸塞州波士顿市社区居民的波士顿地区社区健康调查中使用了1899名30-79岁男性的数据，该调查是在2002年至2005年期间通过面对面访谈，自行管理的调查表和静脉血收集的画。主要观察指标：ED是使用国际勃起功能指数的缩写形式测量的。在过去的一个月中，通过使用抗血脂药定义了治疗的高脂血症病例，而未治疗的高脂血症是血清总胆固醇>或= 240毫克/分升，不使用抗血脂药。我们从多元逻辑回归中使用比值比（OR）和95％置信区间（CI）估计了关联。结果：与未经治疗的高脂血症或没有高脂血症的男性相比，接受过高脂血症治疗的男性年龄更大，合并症和使用的药物更多。在按年龄，糖尿病和/或心血管疾病（CVD）的存在进行分层的多变量模型中，我们发现高脂血症药物治疗与ED之间没有关联，除了患有糖尿病和/或CVD的年轻男性（<55岁）观察到与不精确CI相关联（OR = 10.39，95％CI：3.25，33.20）。在任何多变量模型中，未经治疗的高脂血症和ED之间均无显着的正相关。结论：某些男性中降脂药物可能与ED有关。降低脂质治疗的公认益处应始终权衡潜在的不良反应。

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