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首页> 外文期刊>The Korean Journal of Parasitology >Prevalence of Drug Resistance-Associated Gene Mutations in Plasmodium vivax in Central China
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Prevalence of Drug Resistance-Associated Gene Mutations in Plasmodium vivax in Central China

机译：中国中部间质疟原虫耐药相关基因突变的患病率

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Resistance of Plasmodium spp. to anti-malarial drugs is the primary obstacle in the fight against malaria, and molecular markers for the drug resistance have been applied as an adjunct in the surveillance of the resistance. In this study, we investigated the prevalence of mutations in pvmdr1, pvcrt-o, pvdhfr, and pvdhps genes in temperate-zone P. vivax parasites from central China. A total of 26 isolates were selected, including 8 which were previously shown to have a lower susceptibility to chloroquine in vitro. For pvmdr1, pvcrt-o, and pvdhps genes, no resistance-conferring mutations were discovered. However, a highly prevalent (69.2%), single-point mutation (S117N) was found in pvdhfr gene. In addition, tandem repeat polymorphisms existed in pvdhfr and pvdhps genes, which warranted further studies in relation to the parasite resistance to antifolate drugs. The study further suggests that P. vivax populations in central China may still be relatively susceptible to chloroquine and sulfadoxine-pyrimethamine.
机译：疟原虫的抗性。抗疟疾药物是抗击疟疾的主要障碍，耐药性分子标记已被用作监测耐药性的辅助手段。在这项研究中，我们调查了来自中国中部温带地区间日疟原虫寄生虫中pvmdr1，pvcrt-o，pvdhfr和pvdhps基因突变的普遍性。总共选择了26种分离株，其中8种以前被证明对体外氯喹的敏感性较低。对于pvmdr1，pvcrt-o和pvdhps基因，未发现赋予抗性的突变。然而，在pvdhfr基因中发现了高度流行的（69.2％）单点突变（S117N）。此外，pvdhfr和pvdhps基因中存在串联重复多态性，这需要进一步研究其对叶酸药物的寄生虫抗性。研究进一步表明，中国中部间日疟原虫种群可能仍然相对易受氯喹和磺胺多辛-乙胺嘧啶的影响。

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