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首页> 外文期刊>The Journal of toxicological sciences >Neurotoxic action of inorganic mercury injected in the intraventricular space of mouse cerebrum.
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Neurotoxic action of inorganic mercury injected in the intraventricular space of mouse cerebrum.

机译：无机汞注入小鼠大脑室内空间的神经毒性作用。

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摘要

To examine the neurotoxic action of inorganic mercury, HgCl(2) was injected in the intraventricular space of a mouse brain as a mimic for an Hg(0) vapor-exposed model, and the Hg distribution in the brain and behavioral changes were compared with those of Hg(0)-exposed mice. Although no difference was found in the Hg accumulation and its localization in the brains of two model mice at 3 weeks after Hg treatment, the turnover rate of the brain Hg in the Hg(0)-exposed mice was higher than in the Hg(II)-injected mouse. Despite a similar Hg level in the cerebrum at 3 weeks, behavioral alterations, hyper-activity in an open field test and shortening of latency in a passive avoidance test, were significant only in Hg(II)-injected mice. Considered together with the differences in the turnover rate and the effectiveness of neurotoxic action of the brain Hg, the microenvironment of Hg, such as biomolecules with which Hg interacts, might not be the same in both model mice. Inorganic Hg-induced neurotoxic action could be observed with a minimum dose of Hg(II) without any effects on the other organs, such as the kidney and lung. The present study demonstrated that intraventricular injection of HgCl(2) might be a convenient method to study the neurotoxic action of inorganic Hg, and, at least partly, to represent an animal model of Hg(0) vapor exposure.
机译：为了检查无机汞的神经毒性作用，将HgCl（2）注射到小鼠脑室内空间中，以模拟Hg（0）暴露于蒸气的模型，并将Hg在脑中的分布和行为变化与Hg（0）暴露的小鼠。尽管在汞治疗后3周，在两只模型小鼠的汞积累及其在大脑中的定位方面均未发现差异，但是暴露于Hg（0）的小鼠中脑汞的周转率高于Hg（II） ）注入的鼠标。尽管在3周时大脑中的汞水平相似，但行为改变，开放视野测试中的过度活跃和被动回避测试中潜伏期的缩短仅在注射Hg（II）的小鼠中才有意义。考虑到脑汞的周转率和神经毒性作用有效性的差异，汞的微环境（例如与汞相互作用的生物分子）可能在两只模型小鼠中都不相同。最小剂量的Hg（II）可以观察到无机汞诱导的神经毒性作用，而对其他器官（如肾脏和肺）没有任何影响。本研究表明脑室内注射HgCl（2）可能是研究无机Hg的神经毒性作用的便捷方法，并且至少部分代表了Hg（0）蒸气暴露的动物模型。

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