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首页> 外文期刊>The Journal of toxicological sciences >Systemic toxicity of non-cell corynebacterium parvum (CP) in monkeys.
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Systemic toxicity of non-cell corynebacterium parvum (CP) in monkeys.

机译：小细胞非杆状棒杆菌（CP）对猴子的全身毒性。

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AIM: Non-cell corynebacterium parvum product (NCPP) is a new preparation of corynebacterium parvum (CP), an immunomodulator that displays anticancer activities. It is prepared by nanotechnology and is intended to minimize the side effects of CP. The aim of the present study was to evaluate the immunogenicity and systemic toxicity of NCPP compared with CP in animals. METHODS: 30 monkeys were randomly divided into 5 groups and given CP (3 mg/monkey), three doses of NCPP (9, 3, 1 mg/monkey) and 0.9% normal saline (NS, 4 ml/monkey) individually by intramuscular injection twice a week for 13 weeks. The immunogenicity and systemic toxicity of NCPP and CP were compared. RESULTS: NCCP and CP caused histopathological changes in the liver, spleen and kidney, but pathologic changes in NCCP-treated groups were slighter than that in the CP group. Only 9 mg/monkey of NCPP caused the similar damage as the CP in intensity. Deposition of immune complexes in the glomerular basement membrane was observed only in the CP group. ELISA detection showed that the anti-CP antibody was at a high level, while the anti-NCPP antibody was at low level and disappeared during the recovery period. CONCLUSION: Our study has led to the view that NCPP is safer than CP.
机译：目的：非细胞小棒杆菌产品（NCPP）是一种新的小棒杆菌（CP）制剂，一种具有抗癌活性的免疫调节剂。它是通过纳米技术制备的，旨在最大程度地减少CP的副作用。本研究的目的是评估NCPP与CP相比在动物体内的免疫原性和全身毒性。方法：将30只猴子随机分为5组，分别肌注CP（3毫克/只猴子），三剂NCPP（9、3、1毫克/只猴子）和0.9％生理盐水（NS，4毫升/只猴子）。每周两次注射，持续13周。比较了NCPP和CP的免疫原性和全身毒性。结果：NCCP和CP引起肝脏，脾脏和肾脏的组织病理学改变，但NCCP治疗组的病理学改变比CP组轻。 NCPP仅9毫克/只猴子造成了与CP相似的伤害。仅在CP组中观察到了肾小球基底膜中免疫复合物的沉积。 ELISA检测表明，抗CP抗体水平高，而抗NCPP抗体水平低，在恢复期消失。结论：我们的研究得出的观点是NCPP比CP更安全。

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