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首页> 外文期刊>The Journal of toxicological sciences >Social isolation stress induces hepatic hypertrophy in C57BL/6J mice.
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Social isolation stress induces hepatic hypertrophy in C57BL/6J mice.

机译：社会隔离压力导致C57BL / 6J小鼠肝肥大。

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We previously reported that social isolation stimulated a stress response leading to increasing plasma corticosterone level and disruption of the hepatic lipid metabolism-related pathway, without changing body and organ weights, in mice after 4 weeks of social isolation stress, compared with the grouped-housing control (5 mice/cage). In this study, we evaluated the effects of social isolation stress for an extended period on physiologic changes in male C57BL/6J mice. Plasma corticosterone was reduced after 13 weeks, indicating mice might adapt to social isolation stress. However, body and visceral fat weights were significantly increased in combination with hepatic hypertrophy, and significant decreases in levels of triglyceride and adiponectin in plasma were observed. In conclusion, it is tempting to speculate that mice exposed to social isolation stress for 13 continuous weeks could be at an increased risk of overweight with hepatic hypertrophy. Our results also imply that physiological changes, at least fatty acid metabolism, under stress exposure might be an important factor when evaluating the chronic effects of environmental chemicals.
机译：我们先前曾报道，与成组的住房相比，社会隔离后4周的社交隔离刺激小鼠，其应激反应导致血浆皮质酮水平升高和肝脂质代谢相关途径的破坏，而没有改变体重和器官重量。对照（5只小鼠/笼）。在这项研究中，我们评估了社会隔离压力延长的时间对雄性C57BL / 6J小鼠生理变化的影响。 13周后血浆皮质类固醇减少，表明小鼠可能适应了社会隔离压力。然而，结合肝脏肥大，人体和内脏脂肪的重量显着增加，并且血浆中甘油三酸酯和脂联素的水平显着下降。总之，很容易推测，连续13周暴露于社会隔离压力下的小鼠，肝脏肥大的超重风险增加。我们的研究结果还暗示，在评估环境化学物质的慢性影响时，应力暴露下的生理变化（至少是脂肪酸代谢）可能是重要因素。

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