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首页> 外文期刊>The Journal of toxicological sciences >Branched-chain amino acid-rich diet improves skeletal muscle wasting caused by cigarette smoke in rats
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Branched-chain amino acid-rich diet improves skeletal muscle wasting caused by cigarette smoke in rats

机译：富含支链氨基酸的饮食改善大鼠香烟烟雾引起的骨骼肌消耗

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摘要

Cigarette smoke induces skeletal muscle wasting by a mechanism not yet fully elucidated. Branched-chain amino acids (BCAA) in the skeletal muscles are useful energy sources during exercise or systemic stresses. We investigated the relationship between skeletal muscle wasting caused by cigarette smoke and changes in BCAA levels in the plasma and skeletal muscles of rats. Furthermore, the effects of BCAA-rich diet on muscle wasting caused by cigarette smoke were also investigated. Wistar Kyoto (WKY) rats that were fed with a control or a BCAA-rich diet were exposed to cigarette smoke for four weeks. After the exposure, the skeletal muscle weight and BCAA levels in plasma and the skeletal muscles were measured. Cigarette smoke significantly decreased the skeletal muscle weight and BCAA levels in both plasma and skeletal muscles, while a BCAA-rich diet increased the skeletal muscle weight and BCAA levels in both plasma and skeletal muscles that had decreased by cigarette smoke exposure. In conclusion, skeletal muscle wasting caused by cigarette smoke was related to the decrease of BCAA levels in the skeletal muscles, while a BCAA-rich diet may improve cases of cigarette smoke-induced skeletal muscle wasting.
机译：香烟烟雾通过尚未完全阐明的机制引起骨骼肌消耗。骨骼肌中的支链氨基酸（BCAA）是运动或系统性应激时有用的能源。我们调查了香烟烟雾引起的骨骼肌消耗与大鼠血浆和骨骼肌中BCAA水平变化之间的关系。此外，还研究了富含BCAA的饮食对香烟烟雾引起的肌肉消瘦的影响。用对照或富含BCAA的饮食喂养的Wistar Kyoto（WKY）大鼠暴露于香烟烟雾中四个星期。暴露后，测量血浆和骨骼肌的骨骼肌重量和BCAA水平。香烟烟雾显着降低了血浆和骨骼肌的骨骼肌重量和BCAA水平，而富含BCAA的饮食增加了因接触香烟烟雾而降低的血浆和骨骼肌的骨骼肌重量和BCAA水平。总之，香烟烟雾引起的骨骼肌消耗与骨骼肌中BCAA水平的降低有关，而富含BCAA的饮食可以改善香烟烟雾引起的骨骼肌消耗的情况。

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