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首页> 外文期刊>The Journal of toxicological sciences >Cytokine and eicosanoid profiles of phosphate mine workers
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Cytokine and eicosanoid profiles of phosphate mine workers

机译：磷矿工人的细胞因子和类花生酸谱

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Professional exposures to respirable dusts from phosphate mines are associated with the development of an inflammatory response and airways diseases. This study was performed on 12 phosphate workers versus 8 unexposed controls, including smokers and non-smokers. It consisted of assessing the incidence of phosphate dusts exposure associated or not with smoking on the plasmatic inflammatory status of phosphate mine workers versus controls. The following parameters were studied: hematological profile and plasma level of seven cytokines (IL-1β, IL-6, IL-8, IL-10, IL-12, tumor necrosis Factor (TNF-α), macrophage inflammatory protein (MIP-1β)) and two eicosanoids (leucotriene B-4 (LTB-4) and 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE)) measured by a multiplexed flow cytometric method (CBA: Cytometric Bead Array) or ELISA. In phosphate workers, mainly smokers, the level of white blood cells (WBCs) and lymphocytes (LYM) was significantly higher as compared with controls. This was associated with enhanced levels of IL-1β, IL-6, IL-8, MIP-1β, and LTB-4. In smokers (including phosphate mine workers and controls), the level of LYM was also significantly higher than in controls. Based on a logistic regression analysis, smoker phosphate mine workers have a higher relative risk than controls to have an increase concentration of some cytokines, especially IL-1β, IL-6, IL-8, TNF-α, and MIP-1β. Moreover, the combined effect of smoking and phosphate dusts exposure increases the level of leucocytes as well as the concentration of IL-1β, IL-6, IL-8, MIP1-β, and LTB-4. The present study demonstrates that phosphate dusts are able to trigger a systemic inflammatory reaction characterized by enhanced levels of circulating immunocompetent cells, plasmatic cytokines and eicosanoids, and it establishes that these side effects are enhanced by smoking.
机译：专业暴露于磷酸盐矿产生的可吸入粉尘会导致炎症反应和呼吸道疾病。这项研究是针对12位磷酸盐工作者与8位未暴露的对照组（包括吸烟者和非吸烟者）进行的。它包括评估磷酸盐矿工人与对照组的血浆炎性状况，以评估是否与吸烟相关的磷酸盐尘暴露发生率。研究了以下参数：七种细胞因子（IL-1β，IL-6，IL-8，IL-10，IL-12，肿瘤坏死因子（TNF-α），巨噬细胞炎性蛋白（MIP- 1β））和两种类花生酸（白三烯B-4（LTB-4）和15（S）-羟基二十碳四烯酸（15（S）-HETE））通过多重流式细胞术（CBA：细胞计数微珠阵列）或ELISA测量。在磷酸盐工人（主要是吸烟者）中，白细胞（WBC）和淋巴细胞（LYM）的水平与对照组相比明显更高。这与IL-1β，IL-6，IL-8，MIP-1β和LTB-4的水平升高有关。在吸烟者（包括磷矿工人和控制者）中，LYM水平也显着高于控制者。根据逻辑回归分析，吸烟磷矿工人的相对危险度要高于对照，以增加某些细胞因子，尤其是IL-1β，IL-6，IL-8，TNF-α和MIP-1β的浓度。此外，吸烟和磷酸盐尘暴露的综合作用会增加白细胞的水平以及IL-1β，IL-6，IL-8，MIP1-β和LTB-4的浓度。本研究表明，磷酸盐粉尘能够引发全身性炎症反应，其特征是循环免疫功能细胞，血浆细胞因子和类花生酸的含量增加，并且吸烟可以增强这些副作用。

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