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首页> 外文期刊>The Journal of toxicological sciences >Histopathological analysis for osteomalacia and tubulopathy in itai-itai disease
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Histopathological analysis for osteomalacia and tubulopathy in itai-itai disease

机译：伊泰病的骨软化症和肾小管病变的组织病理学分析

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Background & Aims Cadmium (Cd) is a widespread environmental contaminant that causes both renal tubulopathy and osteomalacia. Osteomalacia is thought to be a result of renal tubulopathy, but there are few studies about the histopathological relationship between the two pathoses. Therefore, in the present study, we examined specimens from cases of itai-itai disease (IID), the most severe form of chronic cadmium poisoning, to evaluate the relationship between them. Methods We analyzed kidney and bone specimens of 61 IID cases and the data regarding Cd concentration in kidney and bone. Tubulopathy was graded on the basis of a three-step scale (mild, moderate, and severe) using the following three items: the degree of proximal tubular defluxion, thickness of renal cortex, and weight of the kidney. Osteomalacia was evaluated using the relative osteoid volume (ROV). Results There were 15 cases of mild, 19 cases of moderate, and 27 cases of severe tubulopathy. The average ROV was 24.9 ± 2.0%. ROV tended to increase as tubulopathy advanced in severity, and ROV was significantly higher in cases with severe tubulopathy than those with mild or moderate tubulopathy. ROV had a negative correlation with Cd concentration in the kidney but no correlation with that in the bone. Conclusions Our results suggest that the development of osteomalacia was related to the development of tubulopathy.
机译：背景与目的镉（Cd）是一种广泛的环境污染物，会导致肾小管病变和骨软化症。骨软化症被认为是肾小管病变的结果，但是关于这两种病之间的组织病理学关系的研究很少。因此，在本研究中，我们检查了伊塔伊塔伊病（IID）（一种最严重的慢性镉中毒形式）的标本，以评估它们之间的关系。方法我们分析了61例IID患者的肾脏和骨骼样本以及有关肾脏和骨骼中Cd浓度的数据。根据以下三个项目，根据三步量表（轻度，中度和重度）对肾病进行分级：近端肾小管脱位程度，肾皮质厚度和肾脏重量。使用相对骨样体积（ROV）评估骨软化症。结果轻度肾小管病变15例，中度19例，重度27例。平均ROV为24.9±2.0％。随着肾小管病变严重程度的增加，ROV趋于增加，重度肾小管病变患者的ROV明显高于轻度或中度肾小管病变患者。 ROV与肾脏中Cd含量呈负相关，但与骨骼中Cd含量无相关性。结论我们的结果表明，骨软化症的发展与肾小管病变的发展有关。

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