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首页> 外文期刊>The Journal of toxicological sciences >Maternal MDMA administration in mice leads to neonatal growth delay
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Maternal MDMA administration in mice leads to neonatal growth delay

机译：小鼠母体MDMA给药导致新生儿生长延迟

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摘要

The psychoactive recreational drug 3,4-methylenedioxymethamphetamine (MDMA) is widely abused. The fact that MDMA induces neurotoxic damage in serotonergic nerve endings is well known. However, the effects of MDMA on pregnant and neonatal animals remain unknown. Therefore, we studied the effects of gestational exposure to MDMA on birth, growth, and behavior of pups. Female BALB/c mice were orally administered either water (10 ml/kg) or MDMA (20 mg/10 ml/kg) from gestational day 1 to postnatal day (P) 21. MDMA did not affect the birth rate, but the survival rate of the pups significantly decreased. A significant reduction in body weight gain was observed in pups from MDMA-administered dams during P3-P21. Maternal MDMA treatment caused an attenuated cliff avoidance reaction and decreased motor function in the pups, as determined by the wire hanging test. These results suggest that MDMA treatment during pregnancy and lactation causes growth retardation and dysfunction of motor neurons in mouse pups.
机译：精神休闲药3,4-亚甲二氧基甲基苯丙胺（MDMA）被广泛滥用。 MDMA在血清素能神经末梢引起神经毒性损伤的事实是众所周知的。但是，MDMA对怀孕和新生动物的影响仍然未知。因此，我们研究了妊娠期接触MDMA对幼仔的出生，生长和行为的影响。从妊娠第1天到出生后（P），口服给雌性BALB / c小鼠水（10 ml / kg）或MDMA（20 mg / 10 ml / kg）口服。MDMA不会影响出生率，但会影响存活率幼崽的比率显着下降。在P3-P21期间，由MDMA给药的水坝幼崽的体重增加明显减少。产妇的MDMA处理导致幼犬的悬崖避让反应减弱，并降低了运动功能，这由电线悬挂测试确定。这些结果表明，妊娠和哺乳期的MDMA治疗会引起小鼠幼鼠生长发育迟缓和运动神经元功能障碍。

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