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首页> 外文期刊>The Journal of toxicological sciences >Impact of legislative changes on patterns of antipsychotic prescribing and self-poisoning in Scotland: 2000-06.
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Impact of legislative changes on patterns of antipsychotic prescribing and self-poisoning in Scotland: 2000-06.

机译：立法变化对苏格兰抗精神病药处方和中毒模式的影响：2000-06。

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Recently, national guidelines have advocated greater use of atypical rather than typical antipsychotics in the treatment of schizophrenia. In addition, there have been safety concerns regarding the potential cardiotoxicity of certain antipsychotics taken in overdose. This has led regulatory authorities in the United Kingdom to restrict the use of thioridazine. The overall impact of these legislative changes on patterns of antipsychotic prescribing has received comparatively little attention. Therefore, we sought to examine the effects on community prescribing practices, and to determine whether this was accompanied by changes in patterns of antipsychotic poisoning. Between 2000-03, there was a rapid decline in the use of typical antipsychotics, whereas the use of atypical antipsychotics increased. The prevalence of atypical and typical antipsychotic prescribing has been approximately equal between 2003-06. During the same study period, hospital admissions due to typical antipsychotic poisoning also declined, however, the effects lagged behind changes in prescribing practice by 2-3 years. These data indicate that legislative changes that restrict the use of thioridazine and other typical antipsychotics are associated with a measurable reduction in the number of hospital admissions due to overdose with these agents.
机译：最近，国家指南主张在精神分裂症的治疗中更多地使用非典型抗精神病药，而不是典型抗精神病药。此外，对于服用过量的某些抗精神病药的潜在心脏毒性，存在安全方面的担忧。这导致英国的监管机构限制使用硫代哒嗪。这些立法变化对抗精神病药物处方方式的总体影响很少受到关注。因此，我们试图研究对社区处方实践的影响，并确定这是否伴随着抗精神病药物中毒方式的改变。在2000-03年间，典型抗精神病药的使用量迅速下降，而非典型抗精神病药的使用量却有所增加。 2003-06年间，非典型和典型的抗精神病药物处方的使用率大致相等。在同一研究期间，因典型的抗精神病药物中毒而入院的人数也有所下降，但是，这种影响落后于处方实践的变化，为2-3年。这些数据表明，限制使用硫代哒嗪和其他典型抗精神病药物的立法变更与因使用这些药物过量导致的住院人数显着减少有关。

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