首页> 外文期刊>The Journal of toxicological sciences >Effect of tiron and its combination with nutritional supplements against vanadium intoxication in female albino rats.
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Effect of tiron and its combination with nutritional supplements against vanadium intoxication in female albino rats.

机译:泰隆及其营养补充剂对白化雌性大鼠钒中毒的影响。

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摘要

In the present study an attempt has been made to evaluate the effect of Tiron along with Zinc, Selenium and Vitamin E against vanadium intoxication in female albino rats. Toxicant caused significant increase in the activities of serum transaminases, serum alkaline phosphatase and lactate dehydrogenase. Significant decrease was observed in blood sugar, serum albumin and triglyceride levels whereas serum proteins, cholesterol and urea levels increased significantly during toxicity (p
机译:在本研究中,已尝试评估Tiron以及锌,硒和维生素E对抗雌性白化病大鼠中的钒中毒的作用。毒物导致血清转氨酶,血清碱性磷酸酶和乳酸脱氢酶的活性显着增加。在毒性期间,血糖,血清白蛋白和甘油三酸酯水平显着下降,而血清蛋白,胆固醇和尿素水平显着增加(p≤0.001)。肝脂质过氧化作用显着增加,而钒给药后在减少的谷胱甘肽中观察到明显的消耗。服用钒后,肝脏中葡萄糖-6-磷酸酶的活性也被显着抑制。接触毒物后,肝脏和肾脏的糖原含量明显增加。与肾脏中酸性磷酸酶升高相反,碱性磷酸酶,腺苷三磷酸酶和琥珀酸脱氢酶的活性受到显着抑制。肝脏和肾脏的组织病理学检查(使用光镜和超微镜研究)也证实了上述发现。已发现用Tiron疗法是有效的,但在Tiron + Se之后再用Tiron + VitE和Tiron + Zn进行了所有参数的显着恢复。

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