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首页> 外文期刊>The Journal of toxicological sciences >CYTOTOXIC PROPERTIES OF DIOSPYROS SEYCHELLARUM EXTRACT
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CYTOTOXIC PROPERTIES OF DIOSPYROS SEYCHELLARUM EXTRACT

机译：鼠尾草提取物的细胞毒性

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摘要

During a recent botanical expedition in the Seychelles archipelago we identified healers using Diospyros seychellarum as a tonic. Since this plant lacks any medicinal record in the current literature, we assessed the cytotoxic potential of D. seychellarum. Using Jurkat cells as a model system we show, by flow cytometry, that treatment with the leaf extract results in mitochondrial depolarization and subsequent loss of cellular membrane integrity. Additionally, by transmission electron microscopy, we show that treatment with the extract results in chromatin condensation, mitochondrial swelling, and loss of nuclear membrane integrity. Through these morphological and biochemical observations we concluded that the extract of Diospyros seychellarum is able to induce apoptosis. While it is difficult to extrapolate a potential pharmacologic function based on the ethnomedical use as a tonic, the ability of this extract to induce apoptosis warrants further investigation of the medicinal properties of this plant.
机译：在塞舌尔群岛最近的一次植物考察中，我们确定了使用Diospyros seychellarum作为补品的治疗师。由于该植物在当前文献中缺乏任何医学记录，因此我们评估了D. seychellarum的细胞毒性潜力。使用Jurkat细胞作为模型系统，我们通过流式细胞仪显示，用叶提取物进行处理会导致线粒体去极化和随后的细胞膜完整性丧失。此外，通过透射电子显微镜，我们显示提取物的处理导致染色质凝结，线粒体肿胀和核膜完整性丧失。通过这些形态和生化观察，我们得出结论，柿叶提取物能够诱导细胞凋亡。虽然很难根据人种学上的用途推断出潜在的药理功能，作为补品，但这种提取物诱导凋亡的能力值得进一步研究该植物的药用特性。

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