• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of toxicological sciences >A time-course characterization of male reproductive toxicity in rats treated with methyl methanesulphonate (MMS).
【24h】

A time-course characterization of male reproductive toxicity in rats treated with methyl methanesulphonate (MMS).

机译：甲磺酸甲酯（MMS）处理的大鼠雄性生殖毒性的时程特征。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Methyl methanesulphonate (MMS), a potent alkylating agent and testicular toxicant, was orally administered to rats for 5 days at doses of 20, 30, and 40 mg/kg. During the recovery period of 5 weeks, males were evaluated for multiple endpoints such as organ weights, fertility, and sperm parameters. The 5-week recovery periods are designated as follows: Day 1 (1 day after final treatment); Week 1, Week 2, Week 3, Week 4, and Week 5 (first, second, third, fourth, and fifth week after final treatment). A clear time-course of dominant lethals was observed. The peak severities of the dominant lethals were observed in Week 2. It was judged that the most sensitive cellular targets for the dominant lethals are late spermatids. Sperm examination revealed a clear time-course and dose-dependent changes in the frequency of sperm morphological abnormalities. The peak severities of the sperm morphological alterations in cauda epididymis were observed in Week 4. Sensitive cellular stages for the induction of sperm morphological abnormalities were judged to be late spermatocytes and early spermatids. The most frequently observed type of morphologically abnormal spermatozoa was tailless sperm, followed by no-hook head sperm. Although the initial cause for both sperm morphological alterations and dominant lethals was suggested to be genetic insult to the germ cells, there were no obvious relationships observed between these two findings.
机译：甲磺酸甲酯（MMS）是一种有效的烷基化剂和睾丸有毒物质，以20、30和40 mg / kg的剂量口服给予大鼠5天。在5周的恢复期内，对男性进行了多个终点评估，例如器官重量，生育力和精子参数。 5周的恢复期指定如下：第1天（最终治疗后1天）;第1周，第2周，第3周，第4周和第5周（最终治疗后的第一，第二，第三，第四和第五周）。观察到明显的主要致死时间过程。在第2周观察到主要致死菌的最高严重度。据判断，主要致死菌最敏感的细胞靶标是晚期精子。精子检查显示出清晰的时间过程和精子形态异常发生频率的剂量依赖性变化。在第4周观察到附睾马尾精子形态变化的高峰。判断诱导精子形态异常的敏感细胞阶段为精子晚期和精子早期。形态异常精子中最常观察到的类型是无尾精子，其次是无钩头精子。尽管提示精子形态改变和主要致死率的最初原因是对生殖细胞的遗传侮辱，但这两个发现之间没有发现明显的关系。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号