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首页> 外文期刊>The Journal of toxicological sciences >Effects of restricted feeding on fetal and placental development in pregnant rabbits.
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Effects of restricted feeding on fetal and placental development in pregnant rabbits.

机译：限制喂养对妊娠兔胎儿和胎盘发育的影响。

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摘要

In our previous study on the effects of restricted feeding on pregnant rabbits (Matsuoka et al., 2009), animals given 20 g/day of diet on and after gestation day 6 (GD 6) showed significant changes in blood coagulation-related parameters suggesting a tendency to bleed and a decrease in serum concentration of progesterone, an important factor to maintain pregnancy, on GD 22, and a half of them showed serum progesterone concentrations less than 4.0 ng/ml which resulted in abortions on and after GD 23. In the present study, the effects of restricted feeding of 20 g/day from GD 6 to GD 22 on embryo-fetal and placental development on GD 23 as well as on blood coagulation-related parameters and serum progesterone concentrations on GD 22 were examined in pregnant rabbits. As compared with the non-restricted feeding (Not-treated, NT) group, the restricted feeding (RF) group showed lower values of platelets, fibrinogen, activated partial thromboplastin time (APTT) and antithrombin III (ATIII) and a longer prothrombin time (PT), reflecting an inhibition of blood coagulation, and a decrease in serum progesterone concentration on GD 22. Cesarean section performed on GD 23 revealed that the RF group showed a tendency towards an increase in the embryo-fetal death index and lower body weights and placental volumes compared with the NT group. Histological examination of the placenta in the RF group revealed that the labyrinth zone was thin and many glycogen-containing cells still remained in the basal zone, suggesting a delay in placental growth.
机译：在我们先前关于限制饲喂对怀孕兔子的影响的研究中（Matsuoka等人，2009），在妊娠第6天（第6天）及之后每天20 g /天饮食的动物显示与凝血相关的参数发生了显着变化，提示GD 22时有流血的趋势，孕激素的血清浓度降低（维持妊娠的重要因素），其中一半的血清孕酮浓度低于4.0 ng / ml，导致GD 23及之后流产。在本研究中，检查了孕妇每天从GD 6到GD 22限饲20 g，对GD 23的胚胎，胎儿和胎盘发育以及凝血相关参数和GD 22血清孕酮浓度的影响。兔子。与非限制性喂养（未治疗，NT）组相比，限制性喂养（RF）组显示血小板，纤维蛋白原，活化部分凝血活酶时间（APTT）和抗凝血酶III（ATIII）的值较低，凝血酶原时间更长（PT），反映了GD 22的血液凝结抑制作用和血清孕酮浓度的降低。在GD 23上进行的剖宫产显示RF组显示出胚胎-胎儿死亡指数增加和体重降低的趋势。和胎盘体积与NT组相比。 RF组胎盘的组织学检查显示，迷路区很薄，许多含糖原的细胞仍留在基底区，提示胎盘生长延迟。

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