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首页> 外文期刊>The Journal of toxicological sciences >Sub-acute toxicity study of a new aminoglycoside etimicin sulphate in swiss albino mice
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Sub-acute toxicity study of a new aminoglycoside etimicin sulphate in swiss albino mice

机译：新型氨基糖苷依替米星硫酸盐对瑞士白化病小鼠的亚急性毒性研究

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摘要

Etimicin sulfate, an ethylization derivative of gentamicin, is a new soluble wide-spectrum synthetic aminoglycoside drug. It has wide antibacterial spectrum with high effect and less cross resistance as compared to other aminoglycosides. In order to further explore its safety and tolerance, we have conducted a subactute toxicity study on swiss albino mice. Results from the present study have elucidated that treatment of etimicin sulfate exerts no significant signs of toxicity at any dose level used in the study. Physiological as well as hematological parameters were unaltered throughout the study. Biochemical examination and histopathology of all organs confirmed no significant alteration at any dose levels. The result of this study has suggested there was no obvious toxicity observed with the treatment of etimicin sulphate. It was found to be a safe alternative for various severe infections.
机译：硫酸依替米星是庆大霉素的乙基化衍生物，是一种新型的可溶性广谱合成氨基糖苷药物。与其他氨基糖苷类相比，它具有广泛的抗菌谱，具有很高的效果，并且具有较小的交叉耐药性。为了进一步探索其安全性和耐受性，我们对瑞士白化病小鼠进行了亚致毒物研究。来自本研究的结果已经阐明，硫酸依替米星的治疗在该研究中使用的任何剂量水平下均未表现出明显的毒性迹象。在整个研究过程中，生理和血液学参数均未改变。所有器官的生化检查和组织病理学证实在任何剂量水平下均无明显变化。这项研究的结果表明，硫酸依替米星的治疗没有观察到明显的毒性。已发现它是各种严重感染的安全替代品。

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