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Induced pluripotent stem cells in long-QT syndrome.

机译:在长QT综合征中诱导多能干细胞。

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to the editor: Moretti et al. (Oct. 7 issue) report that patient-derived pluripotent stem cells recapitulated features of a cardiac disorder through reprogramming. The authors clearly show the directed differentiation of such stem cells into functional cardiac myocytes. With regard to pluripo-tency, they tested for expression of pluripotency markers, but data on teratoma formation were missing. We would be grateful if the authors would provide information on any correlation between functional differentiation and teratoma formation (e.g., whether stem-cell clones with good differentiation potential have a tendency to fail to form teratomas). Although criteria for the authenticity of such cells may vary in the context of specific applications, there has been discussion of whether standards for characterization of these cell lines require teratoma assays.
机译:致编辑:Moretti等。 (10月7日发行)报告说,源自患者的多能干细胞通过重新编程重现了心脏病的特征。作者清楚地表明了这种干细胞定向分化为功能性心肌细胞。关于多能性,他们测试了多能性标志物的表达,但缺少畸胎瘤形成的数据。如果作者能提供有关功能分化与畸胎瘤形成之间任何相关性的信息,我们将不胜感激(例如,具有良好分化潜能的干细胞克隆是否倾向于不形成畸胎瘤)。尽管这些细胞的真实性标准在特定应用的情况下可能会有所不同,但已经讨论了表征这些细胞系的标准是否需要畸胎瘤测定。

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