Reprogramming fibroblasts into cardiomyocytes.

Murry CE; Pu WT

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Reprogramming fibroblasts into cardiomyocytes.

机译：将成纤维细胞重编程为心肌细胞。

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A deficiency of cardiomyocytes underlies most cases of heart failure, and scientists have long sought to repopulate the heart with new cardiomyocytes. Most attempts at remuscularization have been based on the transplantation of stem cells or their derivatives, and success has been modest to date. A recent study by Ieda and colleagues points to a new therapeutic strategy: re-programming fibroblasts to become cardiomyocytes.

机译：心肌细胞缺乏是大多数心力衰竭的基础，长期以来，科学家一直在寻求用新的心肌细胞重新填充心脏。进行肌肉再生的大多数尝试都是基于干细胞或其衍生物的移植，迄今为止，成功还很有限。艾达及其同事的最新研究指出了一种新的治疗策略：将成纤维细胞重新编程为心肌细胞。

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《The New England journal of medicine》 |2011年第2期|共2页
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Murry CE; Pu WT;
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1. Reprogramming fibroblasts into cardiomyocytes. [J] . Murry CE, Pu WT The New England journal of medicine . 2011,第2期

机译：将成纤维细胞重编程为心肌细胞。
2. Reprogrammed astrocytes display higher neurogenic competence, migration ability and cell death resistance than reprogrammed fibroblasts [J] . Progress in Artificial Intelligence . 2020,第1期

机译：重编程的星形胶质细胞显示出比重新编程的成纤维细胞更高的神经源性能力，迁移能力和细胞死亡抵抗力
3. Reprogrammed astrocytes display higher neurogenic competence, migration ability and cell death resistance than reprogrammed fibroblasts [J] . Xiaohuan Xia, Chunhong Li, Yi Wang, Translational Neurodegeneration . 2020,第1期

机译：重编程的星形胶质细胞显示出比重新编程的成纤维细胞更高的神经源性能力，迁移能力和细胞死亡率
4. Differentially Expressed Proteomes of Fibroblast-Derived Pluripotent Stem Cells Using Protein-Based Reprogramming [C] . Yikwon Kim, Hophil Min, Sungyoon Moon, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：使用基于蛋白质的重编程的成纤维细胞衍生多能干细胞的差异表达蛋白质蛋白
5. Direct Reprogramming of Fibroblasts into Diverse Lineage Cells by Epigenetic Modification [D] . YANG DONG WOOK 2019

机译：通过表观遗传修饰将成纤维细胞直接重编程为不同的谱系细胞
6. Triiodothyronine induces over-expression of alpha-smooth muscle actin restricts myofibrillar expansion and is permissive for the action of basic fibroblast growth factor and insulin-like growth factor I in adult rat cardiomyocytes. [O] . M A Gosteli-Peter, B A Harder, H M Eppenberger, 1996

机译：Triiodothyronine诱导α平滑肌肌动蛋白的过表达限制肌原纤维的扩张并允许成年大鼠心肌细胞中碱性成纤维细胞生长因子和胰岛素样生长因子I的作用。
7. Inhibition of TGFβ signaling increases direct conversion of fibroblasts to induced cardiomyocytes. [O] . Jamie L Ifkovits, Russell C Addis, Jonathan A Epstein, 2014

机译：抑制TGFβ信号传导增加成纤维细胞直接转化为诱导的心肌细胞。

Reprogramming fibroblasts into cardiomyocytes.

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