• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The New England journal of medicine >The effect of balloon angioplasty on hypertension in atherosclerotic renal-artery stenosis. Dutch Renal Artery Stenosis Intervention Cooperative Study Group (see comments)
【24h】

The effect of balloon angioplasty on hypertension in atherosclerotic renal-artery stenosis. Dutch Renal Artery Stenosis Intervention Cooperative Study Group (see comments)

机译：球囊血管成形术对动脉粥样硬化性肾动脉狭窄中高血压的影响。荷兰肾动脉狭窄干预合作研究组（请参阅评论）

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Patients with hypertension and renal-artery stenosis are often treated with percutaneous transluminal renal angioplasty. However, the long-term effects of this procedure on blood pressure are not well understood. METHODS: We randomly assigned 106 patients with hypertension who had atherosclerotic renal-artery stenosis (defined as a decrease in luminal diameter of 50 percent or more) and a serum creatinine concentration of 2.3 mg per deciliter (200 micromol per liter) or less to undergo percutaneous transluminal renal angioplasty or to receive drug therapy. To be included, patients also had to have a diastolic blood pressure of 95 mm Hg or higher despite treatment with two antihypertensive drugs or an increase of at least 0.2 mg per deciliter (20 micromol per liter) in the serum creatinine concentration during treatment with an angiotensin-converting-enzyme inhibitor. Blood pressure, doses of antihypertensive drugs, and renal function were assessed at 3 and 12 months, and patency of the renal artery was assessed at 12 months. RESULTS: At base line, the mean (+/-SD) systolic and diastolic blood pressures were 179+/-25 and 104+/-10 mm Hg, respectively, in the angioplasty group and 180+/-23 and 103+/-8 mm Hg, respectively, in the drug-therapy group. At three months, the blood pressures were similar in the two groups (169+/-28 and 99+/-12 mm Hg, respectively, in the 56 patients in the angioplasty group and 176+/-31 and 101+/-14 mm Hg, respectively, in the 50 patients in the drug-therapy group; P=0.25 for the comparison of systolic pressure and P=0.36 for the comparison of diastolic pressure between the two groups); at the time, patients in the angioplasty group were taking 2.1+/-1.3 defined daily doses of medication and those in the drug-therapy group were taking 3.2+/-1.5 daily doses (P<0.001). In the drug-therapy group, 22 patients underwent balloon angioplasty after three months because of persistent hypertension despite treatment with three or more drugs or because of a deterioration in renal function. According to intention-to-treat analysis, at 12 months, there were no significant differences between the angioplasty and drug-therapy groups in systolic and diastolic blood pressures, daily drug doses, or renal function. CONCLUSIONS: In the treatment of patients with hypertension and renal-artery stenosis, angioplasty has little advantage over antihypertensive-drug therapy.
机译：背景：患有高血压和肾动脉狭窄的患者通常接受经皮腔内肾血管成形术治疗。但是，这种方法对血压的长期影响尚不清楚。方法：我们随机分配了106例患有动脉粥样硬化性肾动脉狭窄（定义为管腔直径缩小50％或以上）且血清肌酐浓度为2.3毫克/分升（200微摩尔/升）或以下的高血压患者经皮腔内肾成形术或接受药物治疗。被纳入研究的患者，尽管使用了两种降压药治疗，或者在使用抗抑郁药治疗期间血清肌酐浓度增加了至少0.2 mg /分升（20μmol/升），但患者的舒张压也必须达到95 mm Hg或更高。血管紧张素转换酶抑制剂。在3和12个月时评估血压，降压药剂量和肾功能，在12个月时评估肾动脉的通畅性。结果：在基线时，血管成形术组的平均（+/- SD）收缩压和舒张压分别为179 +/- 25和104 +/- 10 mm Hg，180 +/- 23和103 + /药物治疗组分别为-8 mm Hg。在三个月时，两组的血压相似（血管成形术组的56名患者分别为169 +/- 28和99 +/- 12 mm Hg，176 +/- 31和101 +/- 14药物治疗组的50例患者分别为mm Hg;两组之间的收缩压比较，P = 0.25;舒张压的比较，P = 0.36）;当时，血管成形术组的患者每天服用2.1 +/- 1.3规定的药物剂量，而药物治疗组的患者每天服用3.2 +/- 1.5的剂量（P <0.001）。在药物治疗组中，有22例患者在三个月后进行了球囊血管成形术，这是因为尽管使用了三种或更多种药物治疗仍持续存在高血压，或者由于肾功能恶化。根据意向性治疗分析，在12个月时，血管成形术组和药物治疗组之间的收缩压和舒张压，每日药物剂量或肾功能无显着差异。结论：在高血压和肾动脉狭窄患者的治疗中，血管成形术比抗高血压药物治疗没有什么优势。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号