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首页> 外文期刊>The New England journal of medicine >Selective serotonin-reuptake inhibitors and risk of persistent pulmonary hypertension of the newborn.
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Selective serotonin-reuptake inhibitors and risk of persistent pulmonary hypertension of the newborn.

机译：选择性5-羟色胺再摄取抑制剂和新生儿持续性肺动脉高压的风险。

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BACKGROUND: Persistent pulmonary hypertension of the newborn (PPHN) is associated with substantial infant mortality and morbidity. A previous cohort study suggested a possible association between maternal use of the selective serotonin-reuptake inhibitor (SSRI) fluoxetine late in the third trimester of pregnancy and the risk of PPHN in the infant. We performed a case-control study to assess whether PPHN is associated with exposure to SSRIs during late pregnancy. METHODS: Between 1998 and 2003, we enrolled 377 women whose infants had PPHN and 836 matched control women and their infants. Maternal interviews were conducted by nurses, who were blinded to the study hypothesis, regarding medication use in pregnancy and potential confounders, including demographic variables and health history. RESULTS: Fourteen infants with PPHN had been exposed to an SSRI after the completion of the 20th week of gestation, as compared with six control infants (adjusted odds ratio, 6.1; 95 percent confidence interval, 2.2 to 16.8). In contrast, neither the use of SSRIs before the 20th week of gestation nor the use of non-SSRI antidepressant drugs at any time during pregnancy was associated with an increased risk of PPHN. CONCLUSIONS: These data support an association between the maternal use of SSRIs in late pregnancy and PPHN in the offspring; further study of this association is warranted. These findings should be taken into account in decisions as to whether to continue the use of SSRIs during pregnancy.
机译：背景：持续性新生儿肺动脉高压（PPHN）与婴儿的大量死亡率和发病率有关。先前的一项队列研究表明，孕妇在妊娠中期晚期使用选择性5-羟色胺再摄取抑制剂（SSRI）氟西汀与婴儿患PPHN的风险之间可能存在关联。我们进行了一项病例对照研究，以评估妊娠晚期PPHN是否与SSRIs暴露有关。方法：在1998年至2003年之间，我们纳入了377名婴儿患有PPHN的妇女和836名相匹配的对照妇女及其婴儿。产妇访谈是由护士进行的，他们不了解研究假设，涉及怀孕期间的药物使用情况以及潜在的混杂因素，包括人口统计学变量和健康史。结果：妊娠20周后，有14名PPHN婴儿暴露于SSRI，而对照组为6名婴儿（调整比值比为6.1; 95％的置信区间为2.2至16.8）。相反，在妊娠第20周之前使用SSRIs或在怀孕期间任何时候使用非SSRI抗抑郁药都不会增加PPHN的风险。结论：这些数据支持孕妇在妊娠晚期使用SSRIs与后代中的PPHN之间存在关联。有必要对该关联进行进一步研究。在决定是否在怀孕期间继续使用SSRI时应考虑这些发现。

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