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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Siblings of Okinawan centenarians share lifelong mortality advantages.
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Siblings of Okinawan centenarians share lifelong mortality advantages.

机译：冲绳百岁老人的兄弟姐妹享有终生的死亡率优势。

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摘要

Okinawa, an isolated island prefecture of Japan, has among the highest prevalence of exceptionally long-lived individuals in the world; therefore, we hypothesized that, within this population, genes that confer a familial survival advantage might have clustered. We analyzed the pedigrees of 348 centenarian families with 1142 siblings and compared sibling survival with that of the 1890 Okinawan general population cohort. Both male and female centenarian siblings experienced approximately half the mortality of their birth cohort-matched counterparts. This mortality advantage was sustained and did not diminish with age in contrast to many environmentally based mortality gradients, such as education and income. Cumulative survival advantages for this centenarian sibling cohort increased over the life span such that female centenarian siblings had a 2.58-fold likelihood, and male siblings a 5.43-fold likelihood, versus their birth cohorts, of reaching the age of 90 years. These data support a significant familial component to exceptional human longevity.
机译：冲绳是日本的一个孤岛，在世界上寿命特别长的人中，其发病率最高。因此，我们假设在这个人群中，赋予家族生存优势的基因可能已经聚集。我们分析了348个百岁家庭与1142个同胞的血统，并将同胞存活率与1890年冲绳总人口队列的同胞存活率进行了比较。男性和女性百岁老人的兄弟姐妹都经历了与出生队列匹配的同龄人相比大约一半的死亡率。与许多基于环境的死亡率梯度（例如教育和收入）相比，这种死亡率优势是持续存在的，并且不会随着年龄的增长而减少。该百岁老人同龄人的累积生存优势在整个寿命期内都增加了，使得90岁以下的女性百岁老人同胞的可能性是其出生队列的2.58倍，男性同胞是其5.43倍。这些数据为人类超常寿命提供了重要的家族成分。

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