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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Association of low vitamin D levels with the frailty syndrome in men and women.
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Association of low vitamin D levels with the frailty syndrome in men and women.

机译：低维生素D水平与男性和女性虚弱综合症的关联。

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BACKGROUND: Although both vitamin D (25-hydroxyvitamin D [25(OH)D]) insufficiency and the frailty syndrome are more prevalent in women than men, sex-specific associations have not been explored. We estimated sex-specific associations of low 25(OH)D with frailty. Vitamin D insufficiency can result in hyperparathyroidism, and thus, parathyroid hormone (PTH) was explored as a potential mediator in the relationship between 25(OH)D levels and frailty. METHODS: The sample included 444 male and 561 female participants aged 65 years and older from the InCHIANTI study for whom 25(OH)D levels and frailty information were available. Frailty was defined as the presence of at least three of the five following criteria: slowness, weakness, low energy expenditure, exhaustion, and weight loss. Logistic regression models estimated the association between serum levels of 25(OH)D and PTH with frailty, controlling for potential confounders. RESULTS: Independent of covariates, men with 25(OH)D <50 nmol/L had greater odds of frailty than those with 25(OH)D > or =50 nmol/L (odds ratio [OR] = 4.94, 95% confidence interval [CI] = 1.80-13.61). In women, the adjusted OR for frailty (95% CI) was 1.43 (0.58-3.56). The 25(OH)D ORs differed between men and women (p = .041). ORs changed little after controlling for PTH. However, when low energy expenditure was excluded from the frailty definition, adjusted OR for frailty in men (95% CI) was 2.18 (0.59-8.04); controlling for PTH attenuated this OR by 32%. In women, the OR (95% CI) for frailty (low energy expenditure excluded) was 1.54 (0.31-7.58) and was attenuated by 6% after controlling for PTH. CONCLUSIONS: Vitamin D insufficiency was associated with frailty in men, but not in women. Results suggest that PTH mediates the relationship between 25(OH)D and nonenergy expenditure aspects of frailty.
机译：背景：尽管维生素D（25-羟基维生素D [25（OH）D]）不足和脆弱综合症在女性中的发病率均高于男性，但尚未探索性别特异性的关联。我们估计了25（OH）D低与虚弱的性别特定关联。维生素D不足会导致甲状旁腺功能亢进，因此，甲状旁腺激素（PTH）被认为是25（OH）D水平与体弱之间关系的潜在媒介。方法：该样本包括来自InCHIANTI研究的444名年龄在65岁及以上的男性和561名女性，他们的25（OH）D水平和虚弱信息可用。脆弱被定义为以下五个标准中至少三个存在：缓慢，虚弱，低能量消耗，疲惫和体重减轻。 Logistic回归模型估计血清25（OH）D和PTH与虚弱之间的关联，从而控制潜在的混杂因素。结果：与协变量无关，25（OH）D <50 nmol / L的男性的体弱几率比25（OH）D>或= 50 nmol / L的男性更弱（赔率[OR] = 4.94，置信度95％间隔[CI] = 1.80-13.61）。在女性中，经调整的脆弱性OR值为1.43（0.58-3.56）（95％CI）。男女之间的25（OH）D OR差异（p = .041）。控制PTH后，OR几乎没有变化。然而，当低能量消耗被排除在脆弱的定义之外时，男性脆弱的调整后OR（95％CI）为2.18（0.59-8.04）;控制PTH可使此OR衰减32％。在女性中，身体虚弱的OR（95％CI）（不包括低能量消耗）为1.54（0.31-7.58），控制PTH后衰减了6％。结论：维生素D不足与男性体弱相关，但与女性无关。结果表明，PTH介导了25（OH）D与衰弱的非能量消耗方面之间的关系。

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