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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Concurrent Change in Dehydroepiandrosterone Sulfate and Functional Performance in the Oldest Old: Results From the Cardiovascular Health Study All Stars Study
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Concurrent Change in Dehydroepiandrosterone Sulfate and Functional Performance in the Oldest Old: Results From the Cardiovascular Health Study All Stars Study

机译：老年脱氢表雄酮硫酸盐和功能性能的同时变化：心血管健康研究的结果全明星研究

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Introduction. The correlation between dehydroepiandrosterone sulfate (DHEAS) decline and age led to the hypothesis that DHEAS might be a marker of primary aging, though conflicting data from observational studies of mortality do not support this. We evaluated concurrent DHEAS and functional decline in a very old cohort to test if DHEAS change tracks with functional change during aging. Methods. DHEAS and functional performance (gait speed, grip strength, Modified Mini-Mental State Examination [3MSE] score, and digit symbol substitution test [DSST] score) were measured in 1996-1997 and 2005-2006 in 989 participants in the Cardiovascular Health Study All Stars study (mean age 85.2 years in 2005-2006,63.5% women and 16.5% African American). We used multivariable linear regression to test the association of DHEAS decline with functional decline.Results. After adjustment, each standard deviation decrease in DHEAS was associated with greater declines in gait speed (0.12 m/s, p = .01), grip strength (0.09 kg, p = .03), 3MSE score (0.13 points, p < .001), and DSST score (0.14 points, p = .001) in women only. Additional adjustment for baseline DHEAS attenuated the association with grip strength but did not alter other estimates appreciably, and baseline DHEAS was unassociated with functional decline.Conclusions. In this cohort of very old individuals, DHEAS decline tracked with declines in gait speed, 3MSE score, and DSST score, but not grip strength, in women independent of baseline DHEAS level. DHEAS decline might be a marker for age-associated performance decline, but its relevance is specific to women.
机译：介绍。硫酸脱氢表雄酮（DHEAS）下降与年龄之间的相关性导致以下假设，即DHEAS可能是原发性衰老的标志，尽管来自死亡率观察性研究的相互矛盾的数据并不支持这一点。我们在一个非常老的队列中评估了并发的DHEAS和功能下降，以测试DHEAS在衰老过程中是否随着功能变化而变化。方法。在1996-1997年和2005-2006年期间，对989位心血管健康研究的参与者进行了DHEAS和功能表现（步态速度，抓地力，改良的小精神状态检查[3MSE]分数和数字符号替代测试[DSST]分数）的测量。全明星研究（2005-2006年平均年龄85.2岁，女性占63.5％，非裔美国人占16.5％）。我们使用多元线性回归来检验DHEAS下降与功能下降之间的关系。调整后，DHEAS的每个标准差降低与步态速度（0.12 m / s，p = .01），抓地力（0.09 kg，p = .03），3MSE得分（0.13分，p <。 001）和DSST评分（0.14分，p = .001），仅适用于女性。基线DHEAS的其他调整会减弱与握力的关联性，但不会明显改变其他估计值，基线DHEAS与功能下降无关。在这个非常老的人群中，与基线DHEAS水平无关的女性，DHEAS的下降与步态速度，3MSE得分和DSST得分的下降有关，但与握力无关。 DHEAS下降可能是与年龄相关的性能下降的标志，但它与女性相关。

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