...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Can rodent longevity studies be both short and powerful?
【24h】

Can rodent longevity studies be both short and powerful?

机译：啮齿动物的长寿研究可以短而有力吗？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Many rodent experiments have assessed effects of diets, drugs, genes, and other factors on life span. A challenge with such experiments is their long duration, typically over 3.5 years given rodent life spans, thus requiring significant time costs until answers are obtained. We collected longevity data from 15 rodent studies and artificially truncated them at 2 years to assess the extent to which one will obtain the same answer regarding mortality effects. When truncated, the point estimates were not significantly different in any study, implying that in most cases, truncated studies yield similar estimates. The median ratio of variances of coefficients for truncated to full-length studies was 3.4, implying that truncated studies with roughly 3.4 times as many rodents will often have equivalent or greater power. Cost calculations suggest that shorter studies will be more expensive but perhaps not so much to not be worth the reduced time.
机译：许多啮齿动物实验评估了饮食，药物，基因和其他因素对寿命的影响。这种实验的挑战是它们的持续时间长，在给定啮齿动物寿命的情况下通常超过3。5年，因此需要大量的时间成本才能获得答案。我们从15项啮齿动物研究中收集了寿命数据，并在2年后人工截断了它们，以评估人们对死亡率影响能获得相同答案的程度。被截断的点估计在任何研究中均无显着差异，这意味着在大多数情况下，截断的研究得出相似的估计。截断研究与全长研究的系数方差中位数比率为3.4，这意味着截断研究的啮齿动物数量大约是其3.4倍，通常具有同等或更高的功效。成本计算表明，较短的研究会比较昂贵，但可能不值得花这么短的时间。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号