...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Prevalence of potentially preventable unplanned hospitalizations caused by therapeutic failures and adverse drug withdrawal events among older veterans.
【24h】

Prevalence of potentially preventable unplanned hospitalizations caused by therapeutic failures and adverse drug withdrawal events among older veterans.

机译：在老年退伍军人中，由于治疗失败和不良药物停药事件而导致的潜在可预防的计划外住院的患病率。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background. Studies of drug-related hospitalizations have focused on adverse drug reactions, but few data are available on therapeutic failures (TFs) and adverse drug withdrawal events (ADWEs) leading to hospitalization among community-dwelling older adults. Thus, we sought to describe the prevalence of unplanned hospitalizations caused by TFs and ADWEs. In addition, we evaluated factors associated with these events in a nationally representative sample of older Veterans. Methods. This study included 678 randomly selected unplanned hospitalizations of older (age ≥ 65 years) Veterans between December 1, 2003, and November 9, 2006. The main outcomes were hospitalizations caused by a TF and/or an ADWE as determined by a pair of health professionals from review of medication charts and application of the Therapeutic Failure Questionnaire and/or Naranjo ADWE algorithm, respectively. Preventability (ie, medication error) of the admission was also assessed. Results. Thirty-four TFs and eight ADWEs involving 54 drugs were associated with 40 (5.9%) Veterans' hospitalizations; of these admissions, 90.0% (36/40) were rated as potentially preventable mostly due to medication nonadherence and suboptimal prescribing. The most common TFs that occurred were heart failure exacerbations (n = 8), coronary heart disease symptoms (n = 6), tachyarrhythmias (n = 3), and chronic obstructive pulmonary disease exacerbations (n = 3). Half (4/8) of the ADWEs that occurred were cardiovascular in nature. Multivariable logistic regression modeling indicated that black Veterans (adjusted odds ratio 2.92, 95% CI 1.25-6.80) were significantly more likely to experience a TF-related admission compared with white Veterans. Conclusions. TF-related unplanned hospitalizations occur more frequently than ADWE-related admissions among older Veterans. Almost all TFs and/or ADWEs are potentially preventable.
机译：背景。药物相关住院的研究集中在药物不良反应上，但是关于导致社区住院老年人住院治疗的治疗失败（TF）和不良药物停药事件（ADWE）的数据很少。因此，我们试图描述由TF和ADWE引起的计划外住院的患病率。此外，我们在全国范围内的资深退伍军人样本中评估了与这些事件相关的因素。方法。这项研究包括2003年12月1日至2006年11月9日期间随机选择的678名年龄较大（年龄≥65岁）退伍军人的非计划住院治疗。主要结局是由TF和/或ADWE导致的住院治疗，由一对健康状况决定专业人士分别从药物图表检查和治疗失败调查表和/或Naranjo ADWE算法的应用中获取经验。还评估了入院的可预防性（即用药错误）。结果。涉及54种药物的34个TF和8个ADWE与40例（5.9％）退伍军人住院相关;在这些入院中，有90.0％（36/40）的人被认为是可以预防的，主要是因为药物不坚持和处方不佳。发生的最常见的TF是心力衰竭加重（n = 8），冠心病症状（n = 6），快速性心律失常（n = 3）和慢性阻塞性肺疾病加重（n = 3）。发生的ADWE中有一半（4/8）是心血管性的。多变量logistic回归模型表明，与白人退伍军人相比，黑人退伍军人（调整后的优势比为2.92，95％CI为1.25-6.80）更有可能经历TF相关的入院。结论。在老年退伍军人中，与TF相关的计划外住院比与ADWE相关的入院率更高。几乎所有TF和/或ADWE都是可以预防的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号