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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Life-span extension by caloric restriction is determined by type and level of food reduction and by reproductive mode in Brachionus manjavacas (Rotifera).
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Life-span extension by caloric restriction is determined by type and level of food reduction and by reproductive mode in Brachionus manjavacas (Rotifera).

机译:受热限制的寿命延长取决于减少的食物类型和水平以及繁殖方式(Bartionus manjavacas(Rotifera))。

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摘要

We measured life span and fecundity of three reproductive modes in a clone of the monogonont rotifer Brachionus manjavacas subjected to chronic caloric restriction (CCR) over a range of food concentrations or to intermittent fasting (IF). IF increased life span 50%-70% for all three modes, whereas CCR increased life span of asexual females derived from sexually or asexually produced eggs, but not that of sexual females. The main effect of CR on both asexual modes was to delay death at young ages, rather than to prevent death at middle ages or to greatly extend maximum life span; in contrast CR in sexual females greatly increased the life span of a few long-lived individuals. Lifetime fecundity did not decrease with CCR, suggesting a lack of resource allocation trade-off between somatic maintenance and reproduction. Multiple outcomes for a clonal lineage indicate that different responses are established through epigenetic programming, whereas differences in life-span allocations suggest that multiple genetic mechanisms mediate life-span extension.
机译:我们测量了单性轮虫轮虫Brachionus manjavacas在食物浓度范围内或间歇禁食(IF)范围内遭受长期热量限制(CCR)的克隆中三种繁殖方式的寿命和繁殖力。 IF在这三种模式下的寿命都增加了50%-70%,而CCR则增加了有性或无性产卵的无性雌性的寿命,而无性雌性的无寿命。 CR对这两种无性方式的主要作用是延迟年轻时的死亡,而不是防止中年人死亡或大大延长最大寿命;相反,性女性中的CR大大延长了一些长寿个体的寿命。 CCR的终生繁殖力并未降低,这表明在躯体维持和繁殖之间缺乏资源分配的权衡。克隆谱系的多种结果表明,通过表观遗传程序建立了不同的反应,而寿命分配的差异表明,多种遗传机制介导了寿命的延长。

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