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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Cognitive effects of reducing anticholinergic drug burden in a frail elderly population: A randomized controlled trial
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Cognitive effects of reducing anticholinergic drug burden in a frail elderly population: A randomized controlled trial

机译：减少年老体弱人群抗胆碱药物负担的认知效果：一项随机对照试验

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Background. Observational studies report a relationship between anticholinergic drug scale (ADS) score and cognitive function. This study investigated whether a reduced ADS score improved cognitive function in a frail elderly population.Methods.This randomized, controlled, single-blinded trial, recruited long-term residents with an ADS score of greater than or equal to 3 from 22 nursing homes in Norway. The participants were randomly allocated (1:1) to intervention or control. The intervention was a pharmacist-initiated reduction of ADS score after multidisciplinary drug reviews. Primary end point was Consortium to Establish a Registry for Alzheimer's Disease 10-wordlist test for immediate recall. Secondary end points were Mini-Mental Sate Examination, delayed recall and recognition of words, saliva flow, and serum anticholinergic activity (SAA).The participants were retested after 4 and 8 weeks, and the study groups were compared after adjusting for baseline differences.Results. Eighty-seven patients were included. The median ADS score was reduced by 2 units (p <. 0001) in the intervention group and remained unchanged in the control group. After 8 weeks, the adjusted mean difference in immediate recall was 0.54 words between the intervention and control group (95% confidence interval [CI]:-0.91, 2.05; p =. 48). The study groups did not differ significantly in any of the other cognitive end points, salvia flow, or SAA at either follow-up (p >. 18).Conclusion. Pharmacist-initiated drug changes significantly reduced ADS score but did not improve cognitive function in nursing home residents. Moreover, the drug changes did not reduce SAA or mouth dryness significantly, which might indicate limited applicability of the ADS score to prevent prescription risks in this population. ? 2012 The Author.
机译：背景。观察性研究报告了抗胆碱能药物量表（ADS）评分与认知功能之间的关系。这项研究调查了ADS分数降低是否能改善体弱的老年人群的认知功能。方法：这项随机，对照，单盲试验，从ABC的22家养老院招募了ADS分数大于或等于3的长期居民。挪威。参与者被随机分配（1：1）进行干预或控制。干预是在多学科药物审查后由药剂师发起的ADS评分降低。主要终点是联盟建立了一个针对阿尔茨海默氏病10词表测试的注册表，以便立即召回。次要终点是小精神状态检查，单词的回想和延迟识别，唾液流动以及血清抗胆碱能活性（SAA），参与者在4周和8周后进行了重新测试，并在校正基线差异后比较了研究组。结果。包括八十七名患者。在干预组中，ADS中位数得分降低了2个单位（p <。0001），而在对照组中则保持不变。 8周后，干预组和对照组之间的即时回忆调整后平均差为0.54个字（95％置信区间[CI]：-0.91，2.05; p =。48）。在任何一次随访中，研究组在其他认知终点，丹参流量或SAA方面均无显着差异（p> .18）。药剂师发起的药物变更显着降低了ADS评分，但并未改善疗养院居民的认知功能。此外，药物变化并没有显着降低SAA或口干，这可能表明ADS评分在预防该人群处方风险方面的适用性有限。 ？ 2012作者。

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