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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Respirometric Profiling of Muscle Mitochondria and Blood Cells Are Associated With Differences in Gait Speed Among Community-Dwelling Older Adults
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Respirometric Profiling of Muscle Mitochondria and Blood Cells Are Associated With Differences in Gait Speed Among Community-Dwelling Older Adults

机译：肌肉线粒体和血细胞的呼吸谱分析与社区居住的老年人步态速度的差异相关

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Background. Gait speed provides an integrated measure of physical ability that is predictive of morbidity, disability, and mortality in older adults. Energy demands associated with walking suggest that mitochondrial bioenergetics may play a role in gait speed. Here, we examined the relationship between gait speed and skeletal muscle mitochondrial bioenergetics, and further evaluated whether blood-based bioenergetic profiling might have similar associations with gait speed. Methods. Participants in this study were comprised of two subsets ( n = 17 per subset) and were overweight/obese ( body mass index, 30.9 +/- 2.37), well-functioning, community-dwelling older adults ( 69.1 +/- 3.69 years) without major comorbidity. Gait speeds were calculated from a fast-paced 400 m walk test. Respiratory control ratios were measured from mitochondria isolated from leg skeletal muscle biopsies from one subset. Maximal respiration and spare respiratory capacity were measured from peripheral blood mononuclear cells from the other subset. Results. Individual differences in gait speed correlated directly with respiratory control ratio of mitochondria isolated from skeletal muscle ( r =.536, p =.027) and with both maximal respiration and spare respiratory capacity of peripheral blood mononuclear cells ( r =.585 and p =.014; r =.609 and p =.009, respectively). Conclusions. The bioenergetic profile of mitochondria isolated from skeletal muscle is associated with gait speed in older adults. Blood- based bioenergetic profiling is also associated with gait speed and may provide an alternative measure of mitochondrial function.
机译：背景。步态速度提供了一种综合的身体能力指标，可预测老年人的发病率，残疾和死亡率。与步行相关的能量需求表明线粒体生物能学可能在步态速度中起作用。在这里，我们检查了步态速度与骨骼肌线粒体生物能学之间的关系，并进一步评估了基于血液的生物能谱与步态速度是否具有相似的关联。方法。这项研究的参与者包括两个子集（每个子集n = 17），他们超重/肥胖（体重指数，30.9 +/- 2.37），功能良好的社区居民，老年人（69.1 +/- 3.69岁）没有重大合并症。根据快节奏的400 m步行测试计算步态速度。呼吸控制率是从一个子集的腿部骨骼肌活检物中分离的线粒体中测得的。从其他亚组的外周血单个核细胞中测量最大呼吸和备用呼吸能力。结果。步态速度的个体差异与骨骼肌线粒体的呼吸控制率直接相关（r = .536，p = .027），并且与最大呼吸和外周血单个核细胞的备用呼吸能力有关（r = .585和p = .014; r = .609和p = .009）。结论。从骨骼肌中分离出的线粒体的生物能谱与老年人的步态速度有关。基于血液的生物能谱也与步态速度有关，并可能提供线粒体功能的另一种测量方法。

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