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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Relationship Between Mitochondrial DNA Mutations and Aging. Estimation of Age-at-death
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Relationship Between Mitochondrial DNA Mutations and Aging. Estimation of Age-at-death

机译：线粒体DNA突变与衰老之间的关系。死亡年龄估算

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Some studies have pointed to the relationship between mitochondrial DNA ( mtDNA) mutations and age in different tissues, which are potentially interesting in aging research and in forensic identification because they could help to improve the estimation of age-at-death. The present study aims to evaluate the mutations in mtDNA from dentin and pulp and their relation with age. Healthy erupted third molars were extracted from individuals from two Spanish populations, aged 20-70. When analyzing the amplification of hypervariable region 2 of the mtDNA by real-time polymerase chain reaction, a negative strong linear correlation was found between the mtDNA amplification and age in dentin from both populations. In contrast, a significant correlation between mtDNA amplification and age in pulp was not discovered, probably due to the majority of the mitochondria are placed in dentin. A difference in mtDNA damage between these two populations was also detected, indicating the role of ancestry as a component. The findings from this research enrich the current studies related to aging and mitochondrial damage and provide a new quantitative tool for estimating the age-at-death that, in combination with traditional age markers, could improve identification accuracy in forensic cases.
机译：一些研究指出了线粒体DNA（mtDNA）突变与不同组织中年龄之间的关系，这在衰老研究和法医鉴定中具有潜在的意义，因为它们可以帮助提高死亡时的估计。本研究旨在评估来自牙本质和牙髓的mtDNA突变及其与年龄的关系。健康的第三磨牙是从两个年龄在20-70岁的西班牙人群中提取的。当通过实时聚合酶链反应分析mtDNA的高变区2的扩增时，两个人群的dentin的mtDNA扩增和年龄之间发现负线性强相关。相反，未发现mtDNA扩增与纸浆年龄之间的显着相关性，这可能是由于大多数线粒体都位于牙本质中。还检测到这两个种群之间的mtDNA损伤差异，表明血统作为组成部分的作用。这项研究的发现丰富了与衰老和线粒体损伤有关的当前研究，并提供了一种估计死亡年龄的新定量工具，结合传统年龄标记，可以提高法医病例的识别准确性。

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