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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >The close relationship between biological aging and age-associated pathologies in humans.
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The close relationship between biological aging and age-associated pathologies in humans.

机译：生物衰老与人类年龄相关疾病之间的密切关系。

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摘要

In the last 100 years, there has accumulated a vast amount of information about the changes that accompany aging in a wide range of animal species. At the same time, there has been extensive documentation of the onset and characteristics of age-associated pathologies of humans and other mammals. It is argued that the totality of all this information is interrelated and provides a very extensive description of the deleterious changes in molecules, cells, tissues, and organs, which accompany both aging and many age-associated diseases. The accumulation of damage is in DNA, proteins, membranes, and organelles, as well as the formation of insoluble protein aggregates. The evolved design of many organ systems, such as the cardiovascular system, the brain, and the eye, are incompatible with indefinite survival. The eventual failure to maintain the integrity of tissues and organs is the end result of the multiple causes of aging.
机译：在过去的100年中，已经积累了大量有关各种动物衰老所伴随的变化的信息。同时，已经有大量文献记载了人类和其他哺乳动物与年龄相关的病理学的发作和特征。有人认为，所有这些信息的整体是相互关联的，并提供了对衰老和许多与年龄相关的疾病的分子，细胞，组织和器官的有害变化的非常广泛的描述。损伤的积累是在DNA，蛋白质，膜和细胞器中，以及不溶性蛋白质聚集体的形成。许多器官系统（例如心血管系统，大脑和眼睛）的进化设计与无限期生存不相容。最终无法维持组织和器官的完整性是衰老的多种原因的最终结果。

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