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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >A forty-year follow-up of the Dallas Bed Rest and Training study: the effect of age on the cardiovascular response to exercise in men.
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A forty-year follow-up of the Dallas Bed Rest and Training study: the effect of age on the cardiovascular response to exercise in men.

机译：达拉斯卧床休息和训练研究的四十年随访：年龄对男性运动后心血管反应的影响。

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BACKGROUND: In 1966, five 20-year-old men underwent a comprehensive physiological evaluation of the capacity for adaptation of the cardiovascular system in response to 3 weeks of bed rest and 8 weeks of heavy endurance training; these same participants were reevaluated before and after training at the age of 50. The aim of the present study was to reexamine these same men 40 years following the original assessments. METHODS AND RESULTS: In all three studies, minute ventilation and expired gases were analyzed during exercise testing with Douglas bag collection. Cardiac output (CO) was determined using the acetylene rebreathing technique. Compared with the original 30-year interval, the decline in maximal oxygen uptake (VO(2max)) (-11% vs -25%), maximal CO (+6% vs -11%), and maximal stroke volume (+10% vs -10%) were greater between 50 and 60 years of age. The annualized decline in VO(2max) (55 mL/min/y) between ages 50 and 60 was approximately fourfold higher than the decline between 20 and 50 years (12 mL/min/y). CONCLUSIONS: In the original five participants of the Dallas Bed Rest and Training Study, VO(2max) declined after 40 years of living due to a balanced decrease in central and peripheral determinants of oxygen uptake. The rate of decline in VO(2max) and its components accelerated after the age of 50 years secondary to age and clinical comorbidities. The net proportional decline in VO(2max) for a period of 40 years of life was comparable with that experienced after 3 weeks of strict bed rest at the age of 20 (27% vs 26%, respectively).
机译：背景：1966年，五名20岁男性接受了3周卧床休息和8周重度耐力训练后对心血管系统适应能力的综合生理评估;在50岁的训练前后对这些相同的参与者进行了重新评估。本研究的目的是在最初的评估后40年重新检查这些相同的男人。方法和结果：在全部三项研究中，在运动测试期间使用道格拉斯袋收集器对分钟通气量和排出的气体进行了分析。使用乙炔再呼吸技术确定心输出量（CO）。与最初的30年间隔相比，最大摄氧量（VO（2max））（-11％vs -25％），最大CO（+ 6％vs -11％）和最大中风量（+10）下降％和-10％）在50至60岁之间更高。 50至60岁之间的VO（2max）年度下降（55 mL / min / y）约比20至50岁之间的VO（2max）（12 mL / min / y）下降四倍。结论：在达拉斯卧床休息和训练研究的最初五位参与者中，由于中枢和外围的摄氧决定因素平衡下降，VO（2max）在生活40年后下降。在继发于年龄和临床合并症的50岁以后，VO（2max）及其组分的下降速度加快。在40年的生命中，VO（2max）的净比例下降与20岁时严格卧床休息3周后的净下降比例相当（分别为27％和26％）。

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