...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Effects of exercise and caloric restriction on insulin resistance and cardiometabolic risk factors in older obese adults--a randomized clinical trial.
【24h】

Effects of exercise and caloric restriction on insulin resistance and cardiometabolic risk factors in older obese adults--a randomized clinical trial.

机译：运动和热量限制对老年肥胖成年人胰岛素抵抗和心脏代谢危险因素的影响-一项随机临床试验。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: The prevalence of insulin resistance, metabolic syndrome, and cardiovascular disease is greatest in older obese patients, and effective evidence-based treatment strategies are lacking. METHODS: A prospective controlled study was conducted on 24 older (65.5 +/- 5.0 years) obese (body mass index, 34.3 +/- 5.2 kg/m(2)) adults with clinically diagnosed metabolic syndrome. We examined the effect of exercise alone (EX) or exercise combined with moderate caloric restriction (-500 kcal, EX + CR) on metabolic and cardiovascular risk factors. Measures of insulin sensitivity assessed by euglycemic hyperinsulinemic clamp and by oral glucose tolerance test, lipid profiles, blood pressure, body composition, abdominal fat, and aerobic capacity were all obtained before and after the interventions. RESULTS: Both groups experienced significant weight loss, but the reduction was greater in the EX + CR group than in the EX group (-6.8 +/- 2.7 kg vs -3.7 +/- 3.4 kg, respectively, p = .02). Both interventions improved insulin sensitivity (2.4 +/- 2.4 mg/kg FFM/min and 1.4 +/- 1.7 mg/kgFFM/min, respectively, p < .001) and indices of metabolic syndrome (systolic/diastolic blood pressure, waist circumference, glucose, and triglycerides; p < .05). High-density lipoprotein levels remained unchanged. Total abdominal, subcutaneous, and visceral fat; aerobic capacity; and total and low-density lipoprotein cholesterol were also improved. With the exception of weight loss and subcutaneous fat, there was no difference in the magnitude of improvement between the interventions. CONCLUSION: These data suggest that exercise alone is an effective nonpharmacological treatment strategy for insulin resistance, metabolic syndrome, and cardiovascular disease risk factors in older obese adults.
机译：背景：在老年肥胖患者中，胰岛素抵抗，代谢综合征和心血管疾病的患病率最高，并且缺乏有效的循证医学治疗策略。方法：一项前瞻性对照研究是对24名临床诊断为代谢综合征的肥胖（体重指数，34.3 +/- 5.2 kg / m（2））成年人进行的。我们检查了单独运动（EX）或运动与中度热量限制（-500 kcal，EX + CR）结合对代谢和心血管危险因素的影响。通过干预前和治疗后，通过正常血糖高胰岛素钳夹和口服葡萄糖耐量试验评估的胰岛素敏感性指标，血脂，血压，身体成分，腹部脂肪和有氧运动能力均已获得。结果：两组均出现明显的体重减轻，但EX + CR组的减轻幅度大于EX组（分别为-6.8 +/- 2.7 kg和-3.7 +/- 3.4 kg，p = .02）。两种干预措施均可改善胰岛素敏感性（分别为2.4 +/- 2.4 mg / kg FFM / min和1.4 +/- 1.7 mg / kgFFM / min，p <.001）和代谢综合征的指标（收缩压/舒张压，腰围，葡萄糖和甘油三酸酯; p <.05）。高密度脂蛋白水平保持不变。总腹部，皮下和内脏脂肪;有氧能力总和低密度脂蛋白胆固醇也得到改善。除了减肥和皮下脂肪外，干预之间的改善幅度没有差异。结论：这些数据表明，单独运动是老年肥胖成年人胰岛素抵抗，代谢综合征和心血管疾病危险因素的有效非药物治疗策略。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号