...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Metabolic syndrome and physical decline in older persons: results from the Health, Aging And Body Composition Study.
【24h】

Metabolic syndrome and physical decline in older persons: results from the Health, Aging And Body Composition Study.

机译：老年人的代谢综合症和体力下降：来自健康，衰老和身体成分研究的结果。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: The metabolic syndrome includes dyslipidemia, abdominal obesity, insulin resistance, and hypertension and is associated with an increased risk of diabetes and cerebrovascular disease (CVD), but consequences beyond these outcomes have not been examined extensively. We investigated whether metabolic abnormalities have independent consequences on loss of mobility function of older persons. METHODS: Data are from 2,920 men and women, 70-79 years, participating in the Health ABC study without mobility limitations at baseline. Metabolic syndrome was defined as > or =3 of the following: (a) waist circumference >102 (men) or >88 cm (women); (b) triglycerides > or =150 mg/dL; (c) high-density lipoprotein cholesterol <40 mg/dL (men) or <50 mg/dL (women); (d) blood pressure > or =130/85 mm Hg or antihypertensive medication; and (d) fasting glucose > or =110 mg/dL or antidiabetic medication. Mobility limitation was defined as difficulty or inability walking (1/4) mile or climbing 10 steps during two consecutive semiannual assessments over 4.5 years. RESULTS: The prevalence of metabolic syndrome was 38.6%. The metabolic syndrome was associated with an adjusted relative risk (RR) of 1.46 (95% confidence interval [CI] = 1.30-1.63) for developing mobility limitations. The risk increased when more metabolic syndrome components were present (p trend >.001). All metabolic syndrome components were significantly associated with incident mobility limitations with the highest RRs for abdominal obesity (RR = 1.54, 95% CI = 1.35-1.75) and hyperglycemia (RR = 1.44, 95% CI = 1.27-1.63). Findings were unchanged when persons with baseline, or incident, CVD, stroke, or diabetes were excluded. CONCLUSIONS: Metabolic syndrome abnormalities, especially abdominal obesity and hyperglycemia, are predictive of mobility limitations in the elderly, independent of CVD or diabetes.
机译：背景：代谢综合征包括血脂异常，腹部肥胖，胰岛素抵抗和高血压，并与糖尿病和脑血管疾病（CVD）的风险增加相关，但超出这些结果的后果尚未得到广泛研究。我们调查了代谢异常是否对老年人的活动能力丧失有独立的影响。方法：数据来自2,920名70-79岁的男性和女性，他们参加了健康ABC研究，基线时没有活动受限。代谢综合征定义为以下各项中的>或= 3：（a）腰围> 102（男性）或> 88 cm（女性）; （b）甘油三酸酯>或= 150 mg / dL; （c）高密度脂蛋白胆固醇<40 mg / dL（男性）或<50 mg / dL（女性）; （d）血压>或= 130/85 mm Hg或使用降压药; （d）空腹血糖≥110 mg / dL或抗糖尿病药物。行动不便的定义为在4.5年中连续两次半年度评估中，步行或困难（1/4英里）或爬10步的困难。结果：代谢综合征的患病率为38.6％。代谢综合征与发展为行动不便的调整后相对风险（RR）为1.46（95％置信区间[CI] = 1.30-1.63）相关。当存在更多代谢综合征成分时，风险增加（p趋势> .001）。所有代谢综合征的成分均与入射活动受限有关，腹部肥胖的RR最高（RR = 1.54，95％CI = 1.35-1.75）和高血糖症（RR = 1.44，95％CI = 1.27-1.63）。当排除基线，突发事件，CVD，中风或糖尿病患者时，发现没有变化。结论：代谢综合征异常，尤其是腹部肥胖和高血糖症，可预测老年人的活动受限，与CVD或糖尿病无关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号