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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Obesity, poor muscle strength, and venous thromboembolism in older persons: the InCHIANTI study.
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Obesity, poor muscle strength, and venous thromboembolism in older persons: the InCHIANTI study.

机译：肥胖，肌肉力量差和老年人静脉血栓栓塞：InCHIANTI研究。

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BACKGROUND: Both obesity and the decline in muscle strength, which often occur with aging, are accompanied by functional and metabolic changes that may affect the risk of thrombosis. This study evaluated whether obesity and poor muscle strength are associated with venous thromboembolism (VTE). METHODS: Objectively confirmed VTEs were assessed at baseline and more than a 6-year follow-up in 1,045 participants more than or equal to 60 years enrolled in the InCHIANTI study. RESULTS: At baseline, 97 participants had a positive history of VTE. Obese participants were almost twice more likely (odds ratio 1.76; 95% confidence interval 1.03-3.01) and obese with poor muscle strength were threefold more likely (odds ratio 2.99; 95% confidence interval 1.56-5.73) to have VTE compared with lean participants with normal strength. Fifty-five VTEs occurred during follow-up. History of VTE, obesity, and/or poor strength independently predicted new VTE events. In participants with previous VTE, the odds ratio (95% confidence interval) for thrombosis was 6.64 (1.92-22.95) with poor strength, 9.69 (3.13-30.01) in the obese, and 14.57 (5.16-41.15) in the obese with poor strength as compared with lean participants with normal strength. CONCLUSION: Obesity with or without poor muscle strength is a risk factor for VTE among older persons and significantly amplifies the risk of recurrent thrombosis.
机译：背景：肥胖和肌肉力量下降（通常随年龄增长而发）都伴随着功能和代谢变化，可能会影响血栓形成的风险。这项研究评估了肥胖和肌肉力量差是否与静脉血栓栓塞（VTE）有关。方法：在基线上评估客观确诊的VTE，并在INCHIANTI研究中对6045年以上或以上的1,045名参与者进行了6年以上的随访。结果：基线时，有97名参与者的VTE阳性史。与瘦瘦参与者相比，肥胖参与者发生VTE的几率高几乎两倍（优势比1.76; 95％置信区间1.03-3.01），而肥胖者肌肉力量较弱的可能性高三倍（优势比2.99; 95％置信区间1.56-5.73）。以正常的力量。随访期间发生了55例VTE。 VTE，肥胖和/或体力较弱的病史独立预测了新的VTE事件。曾接受过VTE的参与者中，血栓形成的几率（95％置信区间）为强度欠佳的6.64（1.92-22.95），肥胖者为9.69（3.13-30.01），肥胖者为14.57（5.16-41.15）力量与具有正常力量的瘦人相比。结论：肥胖者肌肉强弱与否是老年人VTE的危险因素，并显着增加了复发性血栓形成的风险。

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