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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >The motor signature of mild cognitive impairment: Results from the gait and brain study
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The motor signature of mild cognitive impairment: Results from the gait and brain study

机译：轻度认知障碍的运动特征：步态和大脑研究的结果

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Background. Early motor changes associated with aging predict cognitive decline, which suggests that a "motor signature" can be detected in predementia states. In line with previous research, we aim to demonstrate that individuals with mild cognitive impairment (MCI) have a distinct motor signature, and specifically, that dual-task gait can be a tool to distinguish amnestic (a-MCI) from nonamnestic MCI. Methods. Older adults with MCI and controls from the "Gait and Brain Study" were assessed with neurocognitive tests to assess cognitive performance and with an electronic gait mat to record temporal and spatial gait parameters. Mean gait velocity and stride time variability were evaluated under simple and three separate dual-task conditions. The relationship between cognitive groups (a-MCI vs nonamnestic MCI) and gait parameters was evaluated with linear regression models and adjusted for confounders. Results. Ninety-nine older participants, 64 MCI (mean age 76.3±7.1 years; 50% female), and 35 controls (mean age 70.4±3.9 years; 82.9% female) were included. Forty-two participants were a-MCI and 22 were nonamnestic MCI. Multivariable linear regression (adjusted for age, sex, physical activity level, comorbidities, and executive function) showed that a-MCI was significantly associated with slower gait and higher dual-task cost under dual-task conditions. Conclusion. Participants with a-MCI, specifically with episodic memory impairment, had poor gait performance, particularly under dual tasking. Our findings suggest that dual-task assessment can help to differentiate MCI subtyping, revealing a motor signature in MCI.
机译：背景。与衰老相关的早期运动变化预示着认知能力下降，这表明在痴呆前状态中可以检测到“运动信号”。与先前的研究一致，我们旨在证明患有轻度认知障碍（MCI）的人具有独特的运动特征，特别是，双任务步态可以成为区分记忆消除（a-MCI）和非记忆消除MCI的工具。方法。患有MCI的老年人和“步态和大脑研究”中的对照通过神经认知测试评估认知表现，并使用电子步态垫记录时间和空间步态参数。在简单和三个独立的双任务条件下评估平均步态速度和步幅时间变异性。使用线性回归模型评估认知组（a-MCI与非记忆MCI）和步态参数之间的关系，并针对混杂因素进行调整。结果。包括九十九名年龄较大的参与者，64名MCI（平均年龄76.3±7.1岁;女​​性50％）和35名对照（平均年龄70.4±3.9岁;女性82.9％）。 42位参与者为a-MCI，22位为非记忆MCI。多变量线性回归（根据年龄，性别，身体活动水平，合并症和执行功能进行调整）显示，a-MCI与双工条件下步态较慢和双工成本较高显着相关。结论。患有a-MCI的参与者，尤其是发作性记忆障碍的参与者，步态表现较差，尤其是在双重任务下。我们的发现表明，双任务评估可以帮助区分MCI亚型，从而揭示MCI中的运动特征。

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