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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Long-term cumulative depressive symptom burden and risk of cognitive decline and dementia among very old women
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Long-term cumulative depressive symptom burden and risk of cognitive decline and dementia among very old women

机译：老年女性的长期累积抑郁症状负担和认知下降和痴呆的风险

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Background.Depressive symptoms and cognitive outcomes are strongly interrelated. Despite that rates of depressive symptoms fluctuate during late life, little is known about the impact of long-term cumulative depressive symptom burden on cognitive decline and dementia in older adults. This study examines the association of nearly 20 years of cumulative depressive symptoms with cognitive outcomes in a cohort of older women.Methods.We assessed depressive symptoms in 7,240 women using the Geriatric Depression scale (GDS) at serial visits. We used a Poisson model with random slopes to estimate GDS trajectories for each participant from baseline to death or end of follow-up, and then characterized depressive symptom burden by quartile of the area under the curve. We assessed cognitive outcomes using repeated measures of the Mini-Mental State Examination (MMSE) and Trails B score over 20 years, Year-20 neuropsychological test battery, and adjudicated dementia and mild cognitive impairment (MCI).Results.Adjusting for potential confounders, compared with women in the lowest quartile of cumulative depressive symptoms burden, women in the highest quartile had 21% more MMSE errors over time (95% CI = 17%, 26%), 20% worse Trails B score over time (95% CI = 17%, 23%), worse scores on most of the Year-20 cognitive tests, and a twofold greater likelihood of developing dementia or MCI (95% CI = 1.48, 3.11).Conclusions.Long-term cumulative depressive symptom burden was associated with cognitive decline and risk of dementia or MCI. Older adults with a history of depression should be closely monitored for recurrent episodes or unresolved depressive symptoms as well as any cognitive deficits.
机译：背景：抑郁症的症状和认知结果密切相关。尽管抑郁症状的发生率在晚年期间有所波动，但对于长期累积的抑郁症状负担对老年人认知能力下降和痴呆的影响知之甚少。这项研究调查了一组老年女性近20年的累积抑郁症状与认知结果的相关性。方法。我们在连续访问时使用老年抑郁量表（GDS）评估了7,240名女性的抑郁症状。我们使用具有随机斜率的Poisson模型来估计每个参与者从基线到死亡或随访结束的GDS轨迹，然后通过曲线下面积的四分位数来表征抑郁症状的负担。我们使用重复测量的迷你精神状态检查（MMSE）和20年以上的Trails B评分，20年级的神经心理学测试电池组，判决的痴呆和轻度认知障碍（MCI）评估了认知结局。与累积抑郁症状负担最低的四分位数的女性相比，最高四分位数的女性随着时间的推移MMSE错误增加21％（95％CI = 17％，26％），随着时间的推移，B轨迹得分降低20％（95％CI = 17％，23％），在20年级大多数认知测试中得分较差，发生痴呆或MCI的可能性增加两倍（95％CI = 1.48，3.11）。长期累积的抑郁症状负担是与认知能力下降和痴呆或MCI风险相关。有抑郁史的老年人应密切监测复发发作或未解决的抑郁症状以及任何认知缺陷。

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