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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Evaluating Health Span in Preclinical Models of Aging and Disease: Guidelines, Challenges, and Opportunities for Geroscience
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Evaluating Health Span in Preclinical Models of Aging and Disease: Guidelines, Challenges, and Opportunities for Geroscience

机译：在老龄化和疾病的临床前模型中评估健康跨度：Geroscience的指南，挑战和机遇

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摘要

Life extension is no longer considered sufficient evidence of delayed aging in research animals. It must also be demonstrated that a broad swathe of health indicators have been extended. During a retreat of the Geroscience Network, a consortium of basic and clinical aging researchers, potential measures of mouse health were considered for their potential as easily standardized, highly informative metrics. Major health domains considered were neuromuscular, cognitive, cardiovascular, metabolic, and inflammatory functions as well as body composition and energetics and a multitude of assays interrogating these domains. A particularly sensitive metric of health is the ability to respond to, and recover, from stress. Therefore, the Network also considered stresses of human relevance that could be implemented in mouse models to assess frailty and resilience. Mouse models already exist for responses to forced immobility, cancer chemotherapy, infectious diseases, dietary challenges, and surgical stress, and it was felt that these could be employed to determine whether putative senescence-retarding interventions increased and extended organismal robustness. The Network discussed challenges in modeling age-related human chronic diseases and concluded that more attention needs to be paid to developing disease models with later age of onset, models of co- and multimorbidity, diversifying the strains and sexes commonly used in aging research, and considering additional species.
机译：寿命延长不再被认为是研究动物延缓衰老的充分证据。还必须证明已扩大了广泛的健康指标。在Geroscience网络（一个由基础和临床衰老研究人员组成的财团）撤退期间，考虑了小鼠健康的潜在测量指标，因为它们的潜力是易于标准化，信息量丰富的指标。所考虑的主要健康领域是神经肌肉，认知，心血管，代谢和炎症功能，以及身体成分和能量学，以及对这些领域进行的大量测定。健康特别敏感的指标是对压力的反应和从中恢复的能力。因此，该网络还考虑了可以在鼠标模型中实现的与人类有关的压力，以评估脆弱性和适应性。小鼠模型已经存在，可以对强迫性不动，癌症化学疗法，传染病，饮食挑战和手术压力做出反应，并且认为可以用这些模型来确定推定的延缓衰老的干预措施是否能增强和增强机体的健壮性。该网络讨论了与年龄有关的人类慢性疾病建模的挑战，并得出结论，需要更多地关注开发发病年龄较晚的疾病模型，合并症和多发病模型，使老化研究中常用的菌株和性别多样化，以及考虑其他物种。

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