Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations

Kraus William E.; Pieper Carl F.; Huffman Kim M.; Thompson Dana K.; Kraus Virginia B.; Morey Miriam C.; Cohen Harvey J.; Ravussin Eric; Redman Leanne M.; Bain James R.; Stevens Robert D.; Newgard Christopher B.

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Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations

机译：在六个不同研究人群中血浆小分子中间代谢物与年龄和体重指数的关联

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Older age and obesity are associated with metabolic dysregulation; the mechanism by which these factors impact metabolism across the lifespan is important, but relatively unknown. We evaluated a panel of amino acids (AAs) and acylcarnitines (ACs) to identify effects of age and adiposity (body mass index) on circulating small-molecule metabolites in a meta-analysis of six diverse study populations.

机译：老年人和肥胖与代谢异常有关。这些因素影响寿命中新陈代谢的机制很重要，但相对未知。在六个不同研究人群的荟萃分析中，我们评估了一组氨基酸（AAs）和酰基肉碱（ACs）以确定年龄和肥胖（体重指数）对循环中小分子代谢产物的影响。

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《The journals of gerontology.Series A. Biological sciences and medical sciences》 |2016年第11期|共7页
作者
Kraus William E.; Pieper Carl F.; Huffman Kim M.; Thompson Dana K.; Kraus Virginia B.; Morey Miriam C.; Cohen Harvey J.; Ravussin Eric; Redman Leanne M.; Bain James R.; Stevens Robert D.; Newgard Christopher B.;
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正文语种 eng
中图分类老年病学;
关键词
Metabolomics; Acylcarnitines; Branched-chain amino acids; Glycine;

机译：代谢组学;酰基肉碱;支链氨基酸;甘氨酸;

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1. Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations [J] . Kraus William E., Pieper Carl F., Huffman Kim M., The journals of gerontology.Series A. Biological sciences and medical sciences . 2016,第11期

机译：在六个不同研究人群中血浆小分子中间代谢物与年龄和体重指数的关联
2. Trans-ethnic fine-mapping of genetic loci for body mass index in the diverse ancestral populations of the Population Architecture using Genomics and Epidemiology (PAGE) Study reveals evidence for multiple signals at established loci [J] . Fernandez-Rhodes Lindsay, Gong Jian, Haessler Jeffrey, Human Genetics . 2017,第6期

机译：使用基因组学和流行病学的人口架构中不同祖先群体的体重指数遗传基因群的跨族 - 群体细制
3. Simultaneous determination of a novel c-Met/AXL dual-target small-molecule inhibitor BPI-9016M and its metabolites in human plasma by liquid chromatography-tandem mass spectrometry: Application in a pharmacokinetic study in Chinese advanced solid tumor patients [J] . Xinge Cui, Xin Zheng, Ji Jiang, Journal of chromatography, B. Analytical technologies in the biomedical and life sciences . 2017,第期

机译：通过液相色谱 - 串联质谱法同时测定人血浆中的新型C-MET / AXL双靶小分子抑制剂BPI-9016M及其代谢物：在中国先进实体肿瘤患者的药代动力学研究中的应用
4. The Association of Urine and Blood Arsenic Metabolites with Body Mass Index in the Bangladesh Fact Study [C] . Ahlam K. Abuawad, Miranda Spratlen, Ana Navas-Acien, Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology . 2018

机译：孟加拉国事实研究中尿液和血液砷代谢物与体重指数的关系
5. Association of body mass index, fruit and vegetable intake and acculturation in a sample Las Vegas Hispanic population. [D] . Bolstad, Anne L. 2010

机译：拉斯维加斯西班牙裔样本中的体重指数，水果和蔬菜的摄入量与适应性的关联。
6. Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations [O] . William E. Kraus, Carl F. Pieper, Kim M. Huffman, -1

机译：六个不同研究人群中血浆小分子中间代谢物与年龄和体重指数的关联
7. Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations [O] . William E. Kraus, Carl F. Pieper, Kim M. Huffman, 2016

机译：血浆小分子中间代谢物与六种不同研究人群的年龄和体重指数的血浆中间代谢物

Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations

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