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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Effects of alterations of glomerular fibrin deposition on renal inflammation in rats at different age stages.
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Effects of alterations of glomerular fibrin deposition on renal inflammation in rats at different age stages.

机译：肾小球纤维蛋白沉积改变对不同年龄阶段大鼠肾脏炎症的影响。

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摘要

Recent data indicated that aging accelerated glomerular fibrin deposition induced by lipopolysaccharide (LPS) in mice. Our hypothesis was that aging may exacerbate glomerular inflammatory responses induced by glomerular fibrin deposition. Both young and aged rats with glomerular fibrin deposition induced by LPS were treated with tranexamic acid (TA) and TA plus urokinase (UK). Infiltrating inflammatory cells and expressions of monocyte chemoattractant protein 1, intercellular adhesion molecule 1, and vascular endothelial-cadherin were markedly upregulated in the LPS+TA group compared with the LPS group. Reduction of fibrin deposition in the LPS+TA+UK group was associated with downregulation of the above indices (p < .05), whereas the alteration of vascular endothelial-cadherin protein expression was negatively correlated with the fibrin deposition. There were also significant differences in increased expressions of monocyte chemoattractant protein 1 and intercellular adhesion molecule 1 between young and aged rats. These in vivo data demonstrated that fibrin deposition contributed to glomerular inflammatory responses, which could be exacerbated by aging.
机译：最新数据表明，衰老加速了小鼠脂多糖（LPS）诱导的肾小球纤维蛋白沉积。我们的假设是衰老可能会加剧由肾小球纤维蛋白沉积引起的肾小球炎症反应。用氨甲环酸（TA）和TA加尿激酶（UK）治疗LPS诱导的肾小球纤维蛋白沉积的年轻和老年大鼠。与LPS组相比，LPS + TA组的浸润性炎症细胞和单核细胞趋化蛋白1，细胞间粘附分子1和血管内皮钙粘蛋白的表达明显上调。 LPS + TA + UK组中纤维蛋白沉积的减少与上述指标的下调相关（p <.05），而血管内皮钙粘蛋白的表达变化与纤维蛋白沉积呈负相关。在年轻和老年大鼠之间，单核细胞趋化蛋白1和细胞间粘附分子1的表达增加也存在显着差异。这些体内数据表明，血纤蛋白沉积促进了肾小球的炎症反应，可能会随着年龄的增长而加剧。

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