...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Orexigenic effects of a growth hormone secretagogue and nitric oxide in aged rats and dogs: correlation with the hypothalamic expression of some neuropeptidergic/receptorial effectors mediating food intake.
【24h】

Orexigenic effects of a growth hormone secretagogue and nitric oxide in aged rats and dogs: correlation with the hypothalamic expression of some neuropeptidergic/receptorial effectors mediating food intake.

机译：生长激素促分泌素和一氧化氮对衰老大鼠和狗的致毒作用：与某些介导食物摄取的神经肽能/受体效应物的下丘脑表达相关。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Hypothalamic neurochemical alterations in mammals underlie disturbances of food intake. There is scarce information on these topics in elderly persons; therefore, the aims of the present study were: (i) to evaluate the orexigenic effects of a growth hormone secretagogue, administered to young and old rats and dogs, alone or in combination with molsidomine, a donor of nitric oxide and (ii) to evaluate by reverse transcription-polymerase chain reaction in the whole hypothalamus of young and old rats messenger RNA levels of a wide number of anabolic and catabolic peptides, receptors, and enzymes involved in the control of feeding behavior, relating the detected titers, whenever possible, to the feeding responses to growth hormone secretagogue. In all, the results obtained strengthen the proposition that, in the hypothalamus of old rats, anti-anorexigenic compensatory mechanisms are operative, aimed at maintaining a "normal" feeding pattern. Thus, the occurrence of a primary, age-related alteration in the feeding mechanisms is unlikely.
机译：哺乳动物的下丘脑神经化学改变是食物摄取障碍的基础。老年人中关于这些主题的信息很少;因此，本研究的目的是：（i）评估单独或与一氧化氮供体莫西多明组合使用的生长激素促分泌素对幼年和老年大鼠和狗的致癌作用，以及（ii）通过逆转录-聚合酶链反应在幼鼠和老鼠整个下丘脑中评估参与进食行为控制的大量合成代谢和分解代谢肽，受体和酶的信使RNA水平，并尽可能与检测到的滴度相关，对生长激素促分泌素的摄食反应。总而言之，获得的结果加强了这样的主张，即在老年大鼠的下丘脑中，抗厌氧补偿机制是有效的，目的是维持“正常”的喂养方式。因此，在喂食机制中不太可能发生与年龄相关的主要变化。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号