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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >PohnB6F1: a cross of wild and domestic mice that is a new model of extended female reproductive life span.
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PohnB6F1: a cross of wild and domestic mice that is a new model of extended female reproductive life span.

机译：PohnB6F1：野生和家养小鼠的杂交，是延长女性生殖寿命的新模型。

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摘要

In the search for novel genetic diversity that affects the timing of life history traits, we investigated a wild-derived stock of mice (Pohn). Early generations showed extended reproductive life span; however, this phenotype diminished with propagation of the stock. Out-crossing latter generation Pohn mice to C57BL/6J (B6) mice produced PohnB6F1 hybrids with remarkably extended reproductive life spans-mean age at last litter of 647 +/- 32 days-longer than for the parental strains (70% longer than Pohn, 88% longer than B6) and longer than for highly heterogeneous crosses of laboratory mice. Litter size among young PohnB6F1 adults was similar to parental stocks, but their age-related decline in litter size was delayed by 150-200 days, resembling the earlier Pohn generations. Possibly, out-crossing Pohn mice unmasked cryptic alleles that promote extended female reproduction. This work establishes the PohnB6F1 hybrid as a new model for delayed reproductive aging.
机译：在寻找影响生活史特征发生时间的新型遗传多样性时，我们调查了野生衍生小鼠（Pohn）。早期世代显示出延长的生殖寿命;但是，这种表型随着种群的繁殖而减少。将后代Pohn小鼠与C57BL / 6J（B6）小鼠杂交后，产生的PohnB6F1杂种的生殖寿命显着延长，平均年龄比最后一次繁殖时长647 +/- 32天（比Pohn菌株长70％） ，比B6长88％），并且比高度异质杂交的实验小鼠更长。年轻的PohnB6F1成年人的产仔量与父母代母猪相似，但与年龄相关的产仔量下降被延迟了150-200天，类似于早期的Pohn代。可能，异型的Pohn小鼠发现了促进雌性繁殖延长的隐性等位基因。这项工作将PohnB6F1杂种确立为延迟生殖衰老的新模型。

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