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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Use of antiplatelet drugs in secondary prevention in older persons with atherothrombotic disease.
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Use of antiplatelet drugs in secondary prevention in older persons with atherothrombotic disease.

机译：抗血小板药物在老年人患有动脉粥样硬化性血栓形成疾病的二级预防中的应用。

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Unless there are contraindications to the use of aspirin, aspirin should be used in treating patients with acute myocardial infarction (MI) and continued indefinitely to reduce vascular death, nonfatal MI, and nonfatal stroke. Clopidogrel added to aspirin has been shown to be beneficial in the treatment of patients with acute ST-elevation MI. Patients with unstable angina or non-ST-elevation MI should be treated with aspirin plus clopidogrel for at least 9 months to reduce vascular death, nonfatal MI, and nonfatal stroke. Patients with prior MI should be treated indefinitely with aspirin and with clopidogrel if aspirin is contraindicated. Patients with ischemic stroke should be treated with either aspirin or clopidogrel indefinitely. Extended release dipyridamole plus low dose aspirin has been shown to be more efficacious than low dose aspirin in only one large study, and is associated with an insignificant increase in nonfatal MI and vascular death over low dose aspirin alone. Clopidogrel is significantly more effective than aspirin in reducing vascular death, nonfatal MI, and nonfatal stroke in patients with peripheral arterial disease.
机译：除非有禁止使用阿司匹林的禁忌症，否则应使用阿司匹林治疗急性心肌梗塞（MI）的患者，并无限期继续使用以减少血管死亡，非致命性MI和非致命性中风。已显示向阿司匹林中添加氯吡格雷对治疗急性ST抬高MI的患者有益。患有不稳定型心绞痛或非ST抬高型MI的患者应接受阿司匹林加氯吡格雷治疗至少9个月，以减少血管性死亡，非致命性MI和非致命性中风。如果禁忌使用阿司匹林，则应先用阿司匹林和氯吡格雷无限期治疗先前有心梗的患者。缺血性中风患者应无限期接受阿司匹林或氯吡格雷治疗。仅在一项大型研究中，缓释双嘧达莫加低剂量阿司匹林比低剂量阿司匹林更有效，并且与非低剂量阿司匹林相比，非致命性心肌梗死和血管死亡的增加无关紧要。氯吡格雷在减少周围动脉疾病患者的血管死亡，非致死性心肌梗死和非致死性卒中方面比阿司匹林有效得多。

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