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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Lipid-Lowering Drugs Associated With Slower Motor Decline in the Elderly Adults
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Lipid-Lowering Drugs Associated With Slower Motor Decline in the Elderly Adults

机译：与老年人运动减慢相关的降脂药物

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Background. Vascular risk factors contribute to motor decline in the elderly persons. We investigated the relationship between lipid-lowering drugs (LLDs) use and decline in walking speed (WS) in older adults. Methods. Data on 4,009 community-dwelling men and women, aged >65 years at baseline, are drawn from the Dijon (France) center of the Three-City study. "Fast" WS was assessed over 6 m at baseline and at 4, 6, 8, and 10 years of follow-up. Mixed linear models were used to determine the relationship between LLDs and change in WS over the follow-up. Results. At baseline, 1,295 beta2%) participants used LLDs (statins, n = 643; fibrates, n - 652); mean fast WS was 152.9cm/s and not significantly different between LLDs users and nonusers. In models adjusted for age. sex, cholesterol level, and other covariates. WS decline was 25% slower in LLDs users (difference with nonusers: 0.58cm/s/y, 95% CI: 0.30. 0.86; p < .001). Both fibrates and statins were associated with slower decline, but only the effect of statins was robust in analyses that took missing values into account. The beneficial effect was more pronounced in those on LLDs continuously over the follow-up. Conclusion. Fast WS declined less in those on LLDs. suggesting that the effect of LLDs. statins in particular, extend beyond that on cardiovascular disease in the elderly persons. However, these effects were modest and their clinical relevance is unclear.
机译：背景。血管危险因素导致老年人运动能力下降。我们调查了降脂药（LLDs）的使用与老年人步行速度（WS）下降之间的关系。方法。基线时年龄大于65岁的4,009名社区居民男女的数据来自三城市研究的第戎（法国）中心。 “快速” WS在基线和随访的4、6、8和10年中超过6 m被评估。在后续研究中，使用混合线性模型确定LLD与WS变化之间的关系。结果。基线时，有1,295个beta2％的参与者使用了LLD（他汀类药物，n = 643;贝特类药物，n-652）;平均快速WS为152.9cm / s，LLD用户和非用户之间无显着差异。在根据年龄调整的型号中。性别，胆固醇水平和其他协变量。 LLD用户的WS下降速度要慢25％（与非用户的差异：0.58cm / s / y，95％CI：0.30.0.86; p <.001）。贝特类药物和他汀类药物均与缓慢的下降有关，但在考虑了缺失值的分析中，只有他汀类药物的作用强。在随访期间，对LLD的有益作用更为明显。结论。 LLD上的快速WS下降幅度较小。提示LLD的效果。他汀类药物尤其适用于老年人的心血管疾病。但是，这些作用尚不明显，其临床相关性尚不清楚。

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