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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Dual effects of resveratrol on arterial damage induced by insulin resistance in aged mice
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Dual effects of resveratrol on arterial damage induced by insulin resistance in aged mice

机译：白藜芦醇对衰老小鼠胰岛素抵抗所致动脉损伤的双重作用

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摘要

Aging leads to increased insulin resistance and arterial dysfunction, with oxidative stress playing an important role. This study explored the metabolic and arterial effects of a chronic treatment with resveratrol, an antioxidant polyphenol compound that has been shown to restore insulin sensitivity and decrease oxidative stress, in old mice with or without a highprotein diet renutrition care. High-protein diet tended to increase insulin resistance and atheromatous risk. Resveratrol improved insulin sensitivity in old mice fed standard diet by decreasing homeostasis model of assessment-insulin resistance and resistin levels. However, resveratrol did not improve insulin resistance status in old mice receiving the high-protein diet. In contrast, resveratrol exhibited deleterious effects by increasing inflammation state and superoxide production and diminishing aortic distensibility. In conclusion, we demonstrate that resveratrol has beneficial or deleterious effects on insulin sensitivity and arterial function, depending on nutritional status in our models.
机译：衰老导致胰岛素抵抗和动脉功能增强，氧化应激起重要作用。这项研究探索了白藜芦醇（一种抗氧化剂多酚化合物）长期治疗的代谢和动脉效应，该化合物已被证明可以在具有或不具有高蛋白饮食营养护理的老年小鼠中恢复胰岛素敏感性并降低氧化应激。高蛋白饮食往往会增加胰岛素抵抗和动脉粥样硬化的风险。白藜芦醇通过降低评估胰岛素抵抗和抵抗素水平的稳态模型，改善了标准饮食喂养的老小鼠的胰岛素敏感性。但是，白藜芦醇不能改善接受高蛋白饮食的老年小鼠的胰岛素抵抗状态。相反，白藜芦醇通过增加炎症状态和产生超氧化物并减少主动脉扩张性而显示出有害作用。总之，我们证明白藜芦醇对胰岛素敏感性和动脉功能具有有益或有害作用，具体取决于我们模型中的营养状况。

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