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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Simple Biologically Informed Inflammatory Index of Two Serum Cytokines Predicts 10 Year All-Cause Mortality in Older Adults
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Simple Biologically Informed Inflammatory Index of Two Serum Cytokines Predicts 10 Year All-Cause Mortality in Older Adults

机译：两种血清细胞因子的简单生物学告知炎症指数可预测老年人的10年全因死亡率。

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Background. Individual measurements of inflammation have been utilized to assess adverse outcomes risk in older adults with varying degrees of success. This study was designed to identify biologically informed, aggregate measures of inflammation for optimal risk assessment and to inform further biological study of inflammatory pathways. Methods. In total, 15 nuclear factor-kappa B-medialed pathway markers of inflammation were first measured in baseline serum samples of 1,155 older participants in the InCHIANTI population. Of these. C-reactive protein, interleukin-1-receptor antagonist, interleukin-6, interleukin-18. and soluble tumor necrosis factor-o. receptor-1 were independent predictors of 5-year mortality. These rive inflammatory markers were measured in baseline serum samples of 5.600 Cardiovascular Health Study participants. A weighted summary score, the first principal component summary score, and an inflammation index score were developed from these five log-transformed inflammatory markers, and their prediction of 10-year all-cause mortality was evaluated in Cardiovascular Health Study and then validated in InCHIANTI. Results. The inflammation index score that included interleukin-6 and soluble tumor necrosis factor-alpha receptor-1 was the best predictor of 10-year all-cause mortality in Cardiovascular Health Study, after adjusting for age, sex, education, race, smoking, and body mass index (hazards ratio = 1.62: 95ac CI: 1.54. 1.70) compared with all other single and combined measures. The inflammation index score was also the best predictor of mortality in the InCHIANTI validation study (hazards ratio 1.33; 95% CI: 1.17-1.52). Stratification by sex and CVD status further strengthened the association of inflammation index score with mortality. captures the effect of chronic inflammation on mortality in older adults among the 15 biomarkers measured.
机译：背景。炎症的个体测量已被用来评估具有不同成功程度的老年人的不良结局风险。这项研究旨在确定生物学方面的炎症综合指标，以进行最佳风险评估，并为炎症途径的进一步生物学研究提供依据。方法。总共在InCHIANTI人群的1,155名年龄较大的参与者的基线血清样本中首先测量了15种核因子-κB介导的炎症信号。这些。 C反应蛋白，白介素1受体拮抗剂，白介素6，白介素18。和可溶性肿瘤坏死因子-o。受体1是5年死亡率的独立预测因子。在5.600心血管健康研究参与者的基线血清样本中测量了这些炎症标记。从这五个经对数转换的炎症标记物得出加权总分，第一主成分总分和炎症指数，并在心血管健康研究中评估了其对10年全因死亡率的预测，然后在INCHIANTI中进行了验证。结果。在对年龄，性别，教育程度，种族，吸烟和年龄进行调整后，包括白细胞介素6和可溶性肿瘤坏死因子α受体1在内的炎症指数评分是心血管健康研究10年全因死亡率的最佳预测指标。体重指数（危险比= 1.62：95ac CI：1.54。1.70）与所有其他单一和综合测量值相比。在InCHIANTI验证研究中，炎症指数评分也是死亡率的最佳预测指标（危险比1.33; 95％CI：1.17-1.52）。按性别和CVD状态进行的分层进一步加强了炎症指数评分与死亡率的关联。捕获了15种生物标志物中慢性炎症对老年人死亡率的影响。

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