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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Number and dosage of central nervous system medications on recurrent falls in community elders: the Health, Aging and Body Composition study.
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Number and dosage of central nervous system medications on recurrent falls in community elders: the Health, Aging and Body Composition study.

机译：社区老年人中反复出现的中枢神经系统药物的数量和剂量下降：健康，衰老和身体成分研究。

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BACKGROUND: Few studies have examined the risk of multiple or high doses of combined central nervous system (CNS) medication use for recurrent falls in the elderly. The study objective was to evaluate whether multiple- or high-dose CNS medication use in older adults was associated with a higher risk of recurrent (>or=2) falls. METHODS: This longitudinal cohort study included 3,055 participants from the Health, Aging and Body Composition study who were well functioning at baseline. CNS medication use (benzodiazepine and opioid receptor agonists, antipsychotics, antidepressants) was determined annually (except Year 4) during in-person interviews. The number and summated standard daily doses (SDDs; low, medium, and high) of CNS medications were computed. Falls 1 year later were ascertained annually for 5 years. RESULTS: For a period of 5 years, as many as 24.1% of CNS medication users took 2+ agents annually, whereas as no more than 18.9% of CNS medication users took high doses annually (3+ SDDs). Yearly,as many as 9.7% of participants reported recurrent falls. Multivariable Generalized Estimating Equation analyses showed that multiple CNS medication users compared with never users had an increased risk of sustaining 2+ falls (adjusted odds ratio [OR] 1.95; 95% confidence interval [CI] 1.35-2.81). Those taking high (3+) CNS SDDs also exhibited an increased risk of 2+ falls (adjusted OR 2.89; 95% CI 1.96-4.25). CONCLUSIONS: Higher total daily doses of CNS medications were associated with recurrent falls. Further studies are needed to determine the impact of reducing the number of CNS medications and/or dosage on recurrent falls.
机译：背景：很少有研究检查了老年人多次跌倒时多次或大剂量联合使用中枢神经系统（CNS）药物的风险。该研究的目的是评估在老年人中使用多剂量或高剂量的中枢神经系统药物是否会引起较高的复发性跌倒风险（>或= 2）。方法：这项纵向队列研究包括来自健康，衰老和身体成分研究的3055名参与者，他们在基线时表现良好。在面对面访问期间（每年4年除外），每年都要确定中枢神经系统药物的使用情况（苯二氮卓和类阿片受体激动剂，抗精神病药，抗抑郁药）。计算中枢神经系统药物的数量和总标准每日剂量（SDD;低，中和高）。 1年后的跌倒被确定为每年5年。结果：在5年的时间里，多达24.1％的CNS药物使用者每年服用2种以上的药物，而不超过18.9％的CNS药物使用者每年服用高剂量（3种以上的SDD）。每年，多达9.7％的参与者报告反复跌倒。多变量广义估计方程分析显示，与从未使用过CNS药物的使用者相比，承受2次以上跌倒的风险增加（调整后的优势比[OR] 1.95; 95％置信区间[CI] 1.35-2.81）。服用高（3+）中枢神经系统SDD的患者，跌倒2+的风险也增加（校正后的OR 2.89; 95％CI 1.96-4.25）。结论：中枢神经系统药物每日总剂量较高与反复跌倒有关。需要进一步研究以确定减少中枢神经系统药物和/或剂量对反复跌倒的影响。

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