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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.
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Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.

机译：雷帕霉素而不是白藜芦醇或辛伐他汀可以延长遗传异质小鼠的寿命。

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摘要

Rapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant increases in life span, including maximum life span, at each of three test sites. Median survival was extended by an average of 10% in males and 18% in females. Rapamycin attenuated age-associated decline in spontaneous activity in males but not in females. Causes of death were similar in control and rapamycin-treated mice. Resveratrol (at 300 and 1200 ppm food) and simvastatin (12 and 120 ppm) did not have significant effects on survival in male or female mice. Further evaluation of rapamycin's effects on mice is likely to help delineate the role of the mammalian target of rapamycin complexes in the regulation of aging rate and age-dependent diseases and may help to guide a search for drugs that retard some or all of the diseases of aging.
机译：从9个月大时开始，雷帕霉素就从食物中施用给异种遗传小鼠，并在三个试验位点的每个部位均显着延长了寿命，包括最大寿命。男性的中位生存期平均延长了10％，女性平均延长了18％。雷帕霉素在男性中减弱了与年龄相关的自发活动的下降，但在女性中却没有。对照组和雷帕霉素治疗小鼠的死亡原因相似。白藜芦醇（在300和1200 ppm的食物中）和辛伐他汀（12和120 ppm）对雄性或雌性小鼠的存活率没有显着影响。雷帕霉素对小鼠的作用的进一步评估可能有助于描述雷帕霉素复合物哺乳动物靶标在调节衰老率和年龄依赖性疾病中的作用，并可能有助于指导寻找可延缓某些或全部疾病的药物。老化。

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