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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Age- and sex-associated plasma proteomic changes in growth hormone receptor gene-disrupted mice.
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Age- and sex-associated plasma proteomic changes in growth hormone receptor gene-disrupted mice.

机译：生长激素受体基因破坏的小鼠的年龄和性别相关的血浆蛋白质组学变化。

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摘要

Growth hormone receptor gene-disrupted (GHR-/-) mice are dwarf, insulin sensitive, and long lived despite being obese. In order to identify characteristics associated with their increased longevity, we studied age-related plasma proteomic changes in these mice. Male and female GHR-/- mice and their littermate controls were followed longitudinally at 8, 16, and 24 months of ages for plasma proteomic analysis. Relative to control littermates, GHR-/- mice had increased levels of apolipoprotein A-4 and retinol-binding protein-4 and decreased levels of apolipoprotein E, haptoglobin, and mannose-binding protein-C. Female GHR-/- mice showed decreased inflammatory cytokines including interleukin-1β and monocyte chemotactic protein-1. Additionally, sex differences were found in specific isoforms of apolipoprotein E, RBP-4, haptoglobin, albumin, and hemoglobin subunit beta. In conclusion, we find plasma proteomic changes in GHR-/- mice that favor a longer life span as well as sex differences indicative of an improved health span in female mice.
机译：生长激素受体基因破坏的小鼠（GHR-/-）矮小，对胰岛素敏感，尽管肥胖，但寿命长。为了确定与其延长寿命相关的特征，我们研究了这些小鼠中与年龄相关的血浆蛋白质组学变化。在8、16和24个月大时纵向追踪雄性和雌性GHR-/-小鼠及其同窝对照，以进行血浆蛋白质组学分析。相对于对照同窝仔，GHR-/-小鼠的载脂蛋白A-4和视黄醇结合蛋白4水平升高，而载脂蛋白E，触珠蛋白和甘露糖结合蛋白C水平降低。雌性GHR-/-小鼠炎症细胞因子减少，包括白介素1β和单核细胞趋化蛋白1。此外，在载脂蛋白E，RBP-4，触珠蛋白，白蛋白和血红蛋白亚基β的特定同工型中发现了性别差异。总之，我们发现GHR-/-小鼠血浆蛋白质组学变化有利于更长的寿命以及性别差异，这表明雌性小鼠的健康期得以改善。

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